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Inhibition of epidermal cell proliferation by borderline rays

Journal Article:

Abstract

Treatment of guinea pig flanks with very soft x-rays (borderline rays) directly caused a partial block of epidermal DNA synthesis which had been determined by measuring the /sup 3/H-Tdr incorporation. Higher doses and repeated applications would undoubtedly cause lasting damage to the tissue. The enhanced epidermal DNA synthesis which is sometimes observed should not be misinterpreted as a sign of a directly biopositive utilisation of the quantum energy supplied. Rather, it is a secondary repair process following initial phases of depression. A reparative increase in DNA synthesis may also occur as a primary process if the radiation is almost completely absorbed above the germinative layer.
Authors:
Born, W; [1]  Daikeler, G
  1. Freiburg Univ.
Publication Date:
Aug 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-07-275471; EDB-77-033120
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 152:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOSYNTHESIS; EPIDERMIS; CELL PROLIFERATION; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; DOSE-RESPONSE RELATIONSHIPS; GUINEA PIGS; INHIBITION; PARTIAL BODY IRRADIATION; SKIN; SOFT X RADIATION; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; ELECTROMAGNETIC RADIATION; EPITHELIUM; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RIBOSIDES; RODENTS; SYNTHESIS; TISSUES; VERTEBRATES; X RADIATION; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7238554
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 172-177
Announcement Date:

Journal Article:

Citation Formats

Born, W, and Daikeler, G. Inhibition of epidermal cell proliferation by borderline rays. Germany: N. p., 1976. Web.
Born, W, & Daikeler, G. Inhibition of epidermal cell proliferation by borderline rays. Germany.
Born, W, and Daikeler, G. 1976. "Inhibition of epidermal cell proliferation by borderline rays." Germany.
@misc{etde_7238554,
title = {Inhibition of epidermal cell proliferation by borderline rays}
author = {Born, W, and Daikeler, G}
abstractNote = {Treatment of guinea pig flanks with very soft x-rays (borderline rays) directly caused a partial block of epidermal DNA synthesis which had been determined by measuring the /sup 3/H-Tdr incorporation. Higher doses and repeated applications would undoubtedly cause lasting damage to the tissue. The enhanced epidermal DNA synthesis which is sometimes observed should not be misinterpreted as a sign of a directly biopositive utilisation of the quantum energy supplied. Rather, it is a secondary repair process following initial phases of depression. A reparative increase in DNA synthesis may also occur as a primary process if the radiation is almost completely absorbed above the germinative layer.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {152:2}
journal type = {AC}
place = {Germany}
year = {1976}
month = {Aug}
}