Abstract
The biological basis for combination therapy with radiation and bleomycin (BLM) was studied on C/sub 2/W cells growing in vitro. When BLM was added to the medium before or after irradiation, a potentiating effect was observed. The potentiation remained for 4-6 hours after irradiation. To make clear the mechanism, both type of repair from radiation damage (Elkind type and PLD) by BLM were examined. BLM didn't inhibit the Elkind type recovery but it did inhibit the repair of potentially lethal damage (PLD repair). Plateau phase C/sub 2/W cells were irradiated, incubated at 37/sup 0/C for a various number of hours, then trypsinized for colony formation. PLD repair was inhibited when BLM was added immediately after irradiation. Based on such experimental results, we treated lung cancer with combination of radiation and BLM. BLM was injected intravenously within 30 minutes after irradiation. Although it seems too early to discuss the result of the combination therapy, it is very promising.
Fukuda, H;
Matsuzawa, T;
Yokoyama, K;
Okuyama, S;
Yamaura, H
[1]
- Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis, Leprosy and Cancer
Citation Formats
Fukuda, H, Matsuzawa, T, Yokoyama, K, Okuyama, S, and Yamaura, H.
Biological basis of combination therapy with radiation and bleomycin.
Japan: N. p.,
1976.
Web.
Fukuda, H, Matsuzawa, T, Yokoyama, K, Okuyama, S, & Yamaura, H.
Biological basis of combination therapy with radiation and bleomycin.
Japan.
Fukuda, H, Matsuzawa, T, Yokoyama, K, Okuyama, S, and Yamaura, H.
1976.
"Biological basis of combination therapy with radiation and bleomycin."
Japan.
@misc{etde_7236728,
title = {Biological basis of combination therapy with radiation and bleomycin}
author = {Fukuda, H, Matsuzawa, T, Yokoyama, K, Okuyama, S, and Yamaura, H}
abstractNote = {The biological basis for combination therapy with radiation and bleomycin (BLM) was studied on C/sub 2/W cells growing in vitro. When BLM was added to the medium before or after irradiation, a potentiating effect was observed. The potentiation remained for 4-6 hours after irradiation. To make clear the mechanism, both type of repair from radiation damage (Elkind type and PLD) by BLM were examined. BLM didn't inhibit the Elkind type recovery but it did inhibit the repair of potentially lethal damage (PLD repair). Plateau phase C/sub 2/W cells were irradiated, incubated at 37/sup 0/C for a various number of hours, then trypsinized for colony formation. PLD repair was inhibited when BLM was added immediately after irradiation. Based on such experimental results, we treated lung cancer with combination of radiation and BLM. BLM was injected intravenously within 30 minutes after irradiation. Although it seems too early to discuss the result of the combination therapy, it is very promising.}
journal = []
volume = {22:2}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Jan}
}
title = {Biological basis of combination therapy with radiation and bleomycin}
author = {Fukuda, H, Matsuzawa, T, Yokoyama, K, Okuyama, S, and Yamaura, H}
abstractNote = {The biological basis for combination therapy with radiation and bleomycin (BLM) was studied on C/sub 2/W cells growing in vitro. When BLM was added to the medium before or after irradiation, a potentiating effect was observed. The potentiation remained for 4-6 hours after irradiation. To make clear the mechanism, both type of repair from radiation damage (Elkind type and PLD) by BLM were examined. BLM didn't inhibit the Elkind type recovery but it did inhibit the repair of potentially lethal damage (PLD repair). Plateau phase C/sub 2/W cells were irradiated, incubated at 37/sup 0/C for a various number of hours, then trypsinized for colony formation. PLD repair was inhibited when BLM was added immediately after irradiation. Based on such experimental results, we treated lung cancer with combination of radiation and BLM. BLM was injected intravenously within 30 minutes after irradiation. Although it seems too early to discuss the result of the combination therapy, it is very promising.}
journal = []
volume = {22:2}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Jan}
}