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Diagnostic radiation and chromosome aberrations

Abstract

Some evidence is presented suggesting that diagnostic X-rays may be important in the origin of a new chromosomal abnormality other than Down syndrome. Chromosome analyses have been carried out on 4342 children, seven or eight years old. Maternal diagnostic irradiation in the year before conception and up to third lunar month of the index pregnancy was recorded, before the chromosome study began, together with a large amount of family and clinical data. Information on X-ray exposure was supplied by the mothers, so radiation dosage could not be estimated. 21 children (including a pair of twins and a pair of siblings) born to 19 mothers had chromosomal aberrations. The mothers of six children with inherited translocations, rearrangements and XYY karyotypes were excluded, and 3 (23%) of the remaining 13 mothers had received abdominal and pelvic X-ray exposures. In the whole sample, however, only 6% of the mothers had diagnostic irradiation. Two of these mothers, aged sixteen and twenty, gave birth to a child each with de-novo autosomal translocations, and the third mother, aged thirty-two, had a child with a complex mosaicism involving one X chromosome. Although the sample size of the mothers with chromosomally abnormal children is small, the results are  More>>
Authors:
Patil, S R; Hecht, F; [1]  Lubs, H A; Kimberling, W; Brown, J; Gerald, P S; Summitt, R L
  1. Dept. of Pediatrics, Child Development and Rehabilitation Center, Univ. of Oregon Health Sciences Center, Portland, Oregon (USA)
Publication Date:
Jan 15, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-298932; EDB-77-064358
Resource Relation:
Journal Name: Lancet; (United Kingdom); Journal Volume: 1:8003
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIOMEDICAL RADIOGRAPHY; RADIATION HAZARDS; CHILDREN; GENETIC RADIATION EFFECTS; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; ETIOLOGY; PRENATAL IRRADIATION; QUANTITY RATIO; STATISTICS; X-RAY RADIOGRAPHY; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DIAGNOSTIC TECHNIQUES; GENETIC EFFECTS; HAZARDS; HEALTH HAZARDS; INDUSTRIAL RADIOGRAPHY; IRRADIATION; MAMMALS; MAN; MATERIALS TESTING; MATHEMATICS; MEDICINE; MUTATIONS; NONDESTRUCTIVE TESTING; NUCLEAR MEDICINE; PRIMATES; RADIATION EFFECTS; RADIOLOGY; TESTING; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7227710
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: LANCA
Submitting Site:
INIS
Size:
Pages: 151
Announcement Date:

Citation Formats

Patil, S R, Hecht, F, Lubs, H A, Kimberling, W, Brown, J, Gerald, P S, and Summitt, R L. Diagnostic radiation and chromosome aberrations. United Kingdom: N. p., 1977. Web. doi:10.1016/S0140-6736(77)91753-6.
Patil, S R, Hecht, F, Lubs, H A, Kimberling, W, Brown, J, Gerald, P S, & Summitt, R L. Diagnostic radiation and chromosome aberrations. United Kingdom. doi:10.1016/S0140-6736(77)91753-6.
Patil, S R, Hecht, F, Lubs, H A, Kimberling, W, Brown, J, Gerald, P S, and Summitt, R L. 1977. "Diagnostic radiation and chromosome aberrations." United Kingdom. doi:10.1016/S0140-6736(77)91753-6. https://www.osti.gov/servlets/purl/10.1016/S0140-6736(77)91753-6.
@misc{etde_7227710,
title = {Diagnostic radiation and chromosome aberrations}
author = {Patil, S R, Hecht, F, Lubs, H A, Kimberling, W, Brown, J, Gerald, P S, and Summitt, R L}
abstractNote = {Some evidence is presented suggesting that diagnostic X-rays may be important in the origin of a new chromosomal abnormality other than Down syndrome. Chromosome analyses have been carried out on 4342 children, seven or eight years old. Maternal diagnostic irradiation in the year before conception and up to third lunar month of the index pregnancy was recorded, before the chromosome study began, together with a large amount of family and clinical data. Information on X-ray exposure was supplied by the mothers, so radiation dosage could not be estimated. 21 children (including a pair of twins and a pair of siblings) born to 19 mothers had chromosomal aberrations. The mothers of six children with inherited translocations, rearrangements and XYY karyotypes were excluded, and 3 (23%) of the remaining 13 mothers had received abdominal and pelvic X-ray exposures. In the whole sample, however, only 6% of the mothers had diagnostic irradiation. Two of these mothers, aged sixteen and twenty, gave birth to a child each with de-novo autosomal translocations, and the third mother, aged thirty-two, had a child with a complex mosaicism involving one X chromosome. Although the sample size of the mothers with chromosomally abnormal children is small, the results are significant.}
doi = {10.1016/S0140-6736(77)91753-6}
journal = {Lancet; (United Kingdom)}
volume = {1:8003}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Jan}
}