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Relation between histamine release and dye permeability of pulmonary blood-air barrier in x-irradiated rat

Journal Article:

Abstract

The histamine-release kinetics and the influence of released histamine on the permeability of the pulmonary blood-air(BA) barrier during the early period after either whole-body or thoracic x irradiation of the rat were studied. Histamine contents of skin and lung of the irradiated rat decreased rapidly, reaching a minimum at 5 h, and this histamine depletion continued for at least 7 days. Conversely, in circulating blood histamine increased during the early period of 5 h and then decreased gradually. This early increase was linear up to 500R and then became saturated between 500 and 1,000R. Administration of polymixine B (5mg/100g body weight) to rats liberated histamine similarly. Rat sera containg histamine released soon after irradiation enhanced the capillary permeability of Evans blue(EB) in the guinea pig skin reaction, which was effectively countered by pretreatment of the guinea pig with anti-histaminic pyribenzamine (29..mu..g/100g body weight), but not by anti-serotonic chlorpromazine (0.3mg/100g body weight). Similarly, perhaps only the EB-bound serum albumin (EB-albumin), that was seen in alveolar perfusate, penetrated more through the pulmonary BA-barrier with increasing x-ray dose, in parallel with the increase in blood histamine. Pyribenzamine inhibited this effect effectively, but cysteamine (a radical scavenger) did so only partially. Thus, it seems  More>>
Authors:
Yamazaki, H [1] 
  1. Kobe Univ. (Japan). School of Medicine
Publication Date:
Apr 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-296193; EDB-77-070559
Resource Relation:
Journal Name: Kobe Daigaku Igakubu Kiyo; (Japan); Journal Volume: 35:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; LOCAL RADIATION EFFECTS; BLOOD CIRCULATION; DOSE-RESPONSE RELATIONSHIPS; GUINEA PIGS; HISTAMINE; LOCAL IRRADIATION; PERMEABILITY; PNEUMONIA; RADIATION INJURIES; RATS; SECRETION; SKIN; TIME DEPENDENCE; WHOLE-BODY IRRADIATION; X RADIATION; AMINES; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7226187
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KIDKA
Submitting Site:
INIS
Size:
Pages: 185-194
Announcement Date:
Mar 01, 1977

Journal Article:

Citation Formats

Yamazaki, H. Relation between histamine release and dye permeability of pulmonary blood-air barrier in x-irradiated rat. Japan: N. p., 1976. Web.
Yamazaki, H. Relation between histamine release and dye permeability of pulmonary blood-air barrier in x-irradiated rat. Japan.
Yamazaki, H. 1976. "Relation between histamine release and dye permeability of pulmonary blood-air barrier in x-irradiated rat." Japan.
@misc{etde_7226187,
title = {Relation between histamine release and dye permeability of pulmonary blood-air barrier in x-irradiated rat}
author = {Yamazaki, H}
abstractNote = {The histamine-release kinetics and the influence of released histamine on the permeability of the pulmonary blood-air(BA) barrier during the early period after either whole-body or thoracic x irradiation of the rat were studied. Histamine contents of skin and lung of the irradiated rat decreased rapidly, reaching a minimum at 5 h, and this histamine depletion continued for at least 7 days. Conversely, in circulating blood histamine increased during the early period of 5 h and then decreased gradually. This early increase was linear up to 500R and then became saturated between 500 and 1,000R. Administration of polymixine B (5mg/100g body weight) to rats liberated histamine similarly. Rat sera containg histamine released soon after irradiation enhanced the capillary permeability of Evans blue(EB) in the guinea pig skin reaction, which was effectively countered by pretreatment of the guinea pig with anti-histaminic pyribenzamine (29..mu..g/100g body weight), but not by anti-serotonic chlorpromazine (0.3mg/100g body weight). Similarly, perhaps only the EB-bound serum albumin (EB-albumin), that was seen in alveolar perfusate, penetrated more through the pulmonary BA-barrier with increasing x-ray dose, in parallel with the increase in blood histamine. Pyribenzamine inhibited this effect effectively, but cysteamine (a radical scavenger) did so only partially. Thus, it seems possible that at soon after x irradiation the enhanced permeability of EB-albumin through the BA barrier of rat lung is due preferentially to the pharmacologic action of released histamine and subsidiarily to radiation damage to pulmonary cells.}
journal = {Kobe Daigaku Igakubu Kiyo; (Japan)}
volume = {35:3}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Apr}
}