You need JavaScript to view this

Studies on the distribution of hematopoietic bone marrow by bone marrow scintigraphy, 3. The bone marrow scintigraphy with /sup 111/In-chloride

Journal Article:

Abstract

A study was made to determine wheter or not bone marrow scintigraphy with /sup 111/In chloride delineates the real distribution of hematopoietic cells. In a patient with acute myelogenous luekemia at the stage of complete remission, there was a significant incorporation of /sup 111/In into bone marrow cells (20 - 28% compared with 6% in the controls). Incorporation of /sup 111/In into peripheral blood cells was 0 at after 10 hours and 5% to 6% after 7 days. The plasma disappearance curve of /sup 111/In consisted of 2 exponential components, one with a half-life of 6.5 to 9.5 hours followed by a slow component with a half-life of 20 to 30 hours. 5 to 7% of the injected dose was excreted in the urine in 24 hours. The distribution of active marrow was investigated with bone marrow scintigraphy in various hematological disorders and the results were compared with those obtained with sup(99m)Tc sulfur colloid. The results obtained in this study suggest that /sup 111/In is incorporated into erythroid precursors, and that this property of /sup 111/In makes in an ideal bone marrow scanning agent for observation of real hematopoietic bone marrow distribution in blood disease.
Authors:
Fujimori, K [1] 
  1. Kyoto Univ. (Japan). Faculty of Medicine
Publication Date:
Apr 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-296415; EDB-77-076422
Resource Relation:
Journal Name: Nippon Ketsueki Gakkai Zasshi; (Japan); Journal Volume: 39:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; SCINTISCANNING; INDIUM 111; ANEMIAS; INDIUM CHLORIDES; LABELLED COMPOUNDS; MYELOID LEUKEMIA; PATIENTS; RADIONUCLIDE KINETICS; BETA DECAY RADIOISOTOPES; BODY; CHLORIDES; CHLORINE COMPOUNDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; INDIUM COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKEMIA; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPTOMS; TISSUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7224266
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NKGZA
Submitting Site:
INIS
Size:
Pages: 131-137
Announcement Date:
Apr 01, 1977

Journal Article:

Citation Formats

Fujimori, K. Studies on the distribution of hematopoietic bone marrow by bone marrow scintigraphy, 3. The bone marrow scintigraphy with /sup 111/In-chloride. Japan: N. p., 1976. Web.
Fujimori, K. Studies on the distribution of hematopoietic bone marrow by bone marrow scintigraphy, 3. The bone marrow scintigraphy with /sup 111/In-chloride. Japan.
Fujimori, K. 1976. "Studies on the distribution of hematopoietic bone marrow by bone marrow scintigraphy, 3. The bone marrow scintigraphy with /sup 111/In-chloride." Japan.
@misc{etde_7224266,
title = {Studies on the distribution of hematopoietic bone marrow by bone marrow scintigraphy, 3. The bone marrow scintigraphy with /sup 111/In-chloride}
author = {Fujimori, K}
abstractNote = {A study was made to determine wheter or not bone marrow scintigraphy with /sup 111/In chloride delineates the real distribution of hematopoietic cells. In a patient with acute myelogenous luekemia at the stage of complete remission, there was a significant incorporation of /sup 111/In into bone marrow cells (20 - 28% compared with 6% in the controls). Incorporation of /sup 111/In into peripheral blood cells was 0 at after 10 hours and 5% to 6% after 7 days. The plasma disappearance curve of /sup 111/In consisted of 2 exponential components, one with a half-life of 6.5 to 9.5 hours followed by a slow component with a half-life of 20 to 30 hours. 5 to 7% of the injected dose was excreted in the urine in 24 hours. The distribution of active marrow was investigated with bone marrow scintigraphy in various hematological disorders and the results were compared with those obtained with sup(99m)Tc sulfur colloid. The results obtained in this study suggest that /sup 111/In is incorporated into erythroid precursors, and that this property of /sup 111/In makes in an ideal bone marrow scanning agent for observation of real hematopoietic bone marrow distribution in blood disease.}
journal = {Nippon Ketsueki Gakkai Zasshi; (Japan)}
volume = {39:2}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Apr}
}