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Diagnosis of hepatocellular carcinoma by serial determination of serum alpha-fetoprotein concentration

Journal Article:

Abstract

This communication describes the clinical significance of serum ..cap alpha..-fetoprotein (S-AFP) determined by radioimmunoassay (RIA) in the diagnosis of hepatocellular carcinoma (HCC). The sensitivity of the AFP assay with the ..cap alpha..-Feto-125 kit produced by the Dainabot RI laboratories was over 2.5 ng/ml. Reproducibility of the kit was satisfactory; coefficient of variation was 6-10% within assays and 13% between assays. The mean and standard deviation of S-AFP in the sera of 30 healthy controls was 5.6+-2.6 ng/ml. When serum with a high level of S-AFP (2.9x10/sup 5/ ng/ml) was diluted with normal horse serum, the actual concentrations of AFP in the diluted serum were consistent with those determined. Thus, normal horse serum was employed to dilute the sera with high levels of AFP. Levels of S-AFP were over 2000 ng/ml in 75.5% of 49 cases with HCC, in 0.64% of 157 patients with hepatitis and cirrhosis of the liver, and in 3.8% of 52 cases of metastatic gastric cancer to the liver. In 20 patients with HCC, levels of S-AFP ranged widely from 7.5 to 9.5x10/sup 5/ ng/ml. In serial determinations of S-AFP in the clinical courses of patients such as those with S-AFP over 2000 ng/ml, the continuous increase  More>>
Authors:
Yumoto, Y; Namba, T; Tanaka, Y; Taketa, K; Ohta, Y [1] 
  1. Okayama Univ. (Japan). School of Medicine
Publication Date:
Jun 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-296456; EDB-77-076441
Resource Relation:
Journal Name: Nippon Shokakibyo Gakkai Zasshi; (Japan); Journal Volume: 73:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; DIAGNOSIS; PROTEINS; RADIOIMMUNOASSAY; BLOOD SERUM; HEPATITIS; HEPATOMAS; IODINE 125; RADIOPHARMACEUTICALS; REFERENCE MAN; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7224262
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NIPAA
Submitting Site:
INIS
Size:
Pages: 659-667
Announcement Date:
Apr 01, 1977

Journal Article:

Citation Formats

Yumoto, Y, Namba, T, Tanaka, Y, Taketa, K, and Ohta, Y. Diagnosis of hepatocellular carcinoma by serial determination of serum alpha-fetoprotein concentration. Japan: N. p., 1976. Web.
Yumoto, Y, Namba, T, Tanaka, Y, Taketa, K, & Ohta, Y. Diagnosis of hepatocellular carcinoma by serial determination of serum alpha-fetoprotein concentration. Japan.
Yumoto, Y, Namba, T, Tanaka, Y, Taketa, K, and Ohta, Y. 1976. "Diagnosis of hepatocellular carcinoma by serial determination of serum alpha-fetoprotein concentration." Japan.
@misc{etde_7224262,
title = {Diagnosis of hepatocellular carcinoma by serial determination of serum alpha-fetoprotein concentration}
author = {Yumoto, Y, Namba, T, Tanaka, Y, Taketa, K, and Ohta, Y}
abstractNote = {This communication describes the clinical significance of serum ..cap alpha..-fetoprotein (S-AFP) determined by radioimmunoassay (RIA) in the diagnosis of hepatocellular carcinoma (HCC). The sensitivity of the AFP assay with the ..cap alpha..-Feto-125 kit produced by the Dainabot RI laboratories was over 2.5 ng/ml. Reproducibility of the kit was satisfactory; coefficient of variation was 6-10% within assays and 13% between assays. The mean and standard deviation of S-AFP in the sera of 30 healthy controls was 5.6+-2.6 ng/ml. When serum with a high level of S-AFP (2.9x10/sup 5/ ng/ml) was diluted with normal horse serum, the actual concentrations of AFP in the diluted serum were consistent with those determined. Thus, normal horse serum was employed to dilute the sera with high levels of AFP. Levels of S-AFP were over 2000 ng/ml in 75.5% of 49 cases with HCC, in 0.64% of 157 patients with hepatitis and cirrhosis of the liver, and in 3.8% of 52 cases of metastatic gastric cancer to the liver. In 20 patients with HCC, levels of S-AFP ranged widely from 7.5 to 9.5x10/sup 5/ ng/ml. In serial determinations of S-AFP in the clinical courses of patients such as those with S-AFP over 2000 ng/ml, the continuous increase of AFP was strongly suggestive of the presence of HCC. In 4 of 20 cases of HCC, the S-AFP levels remained under 300 ng/ml. Histological examination of these 4 cases of HCC showed Classes I and II, but no III in Edmondson's classification. Other cases of HCC with S-AFP levels over 300 ng/ml showed Edmondson's Classes II and III.}
journal = {Nippon Shokakibyo Gakkai Zasshi; (Japan)}
volume = {73:6}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Jun}
}