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Repair of uv damaged DNA in systemic lupus erythematosus. [Mice]

Journal Article:

Abstract

The NZB NZW hybrid mouse is an animal model of human systemic lupus erythematosus (SLE). Two breeding schemes were devised using NZB, NZW, B/W, and CBA mice, which permit definitive decisions regarding genetic and/or viral origin of the disease. It is proposed that at least two factors must be involved: a genetic abnormality producing hyper-responsiveness to nucleic acid antigens, and a DNA repair defect which results in liberation of DNA and RNA when cells are lethally injured. Evidence is presented for a DNA repair deficit in human SLE lymphocytes following in vitro irradiation with ultraviolet (uv) light. Lymphocytes from adult New Zealand and control mice were found to lack normal amounts of endonuclease necessary for repairing uv damage.
Publication Date:
Jun 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-77-083711
Resource Relation:
Journal Name: J. Rheumatol.; (Canada); Journal Volume: 2:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL REPAIR; LUPUS; LYMPHOCYTES; BIOLOGICAL RADIATION EFFECTS; GENETICS; HYBRIDIZATION; MICE; NUCLEASES; RNA; ULTRAVIOLET RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BIOLOGY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; ENZYMES; INFECTIOUS DISEASES; LEUKOCYTES; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHOSPHOTRANSFERASES; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RODENTS; SKIN DISEASES; SOMATIC CELLS; TRANSFERASES; TUBERCULOSIS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7223069
Country of Origin:
Canada
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JRHUA
Submitting Site:
TIC
Size:
Pages: 149-160
Announcement Date:
Jun 01, 1977

Journal Article:

Citation Formats

Beighlie, D J, and Teplitz, R L. Repair of uv damaged DNA in systemic lupus erythematosus. [Mice]. Canada: N. p., 1975. Web.
Beighlie, D J, & Teplitz, R L. Repair of uv damaged DNA in systemic lupus erythematosus. [Mice]. Canada.
Beighlie, D J, and Teplitz, R L. 1975. "Repair of uv damaged DNA in systemic lupus erythematosus. [Mice]." Canada.
@misc{etde_7223069,
title = {Repair of uv damaged DNA in systemic lupus erythematosus. [Mice]}
author = {Beighlie, D J, and Teplitz, R L}
abstractNote = {The NZB NZW hybrid mouse is an animal model of human systemic lupus erythematosus (SLE). Two breeding schemes were devised using NZB, NZW, B/W, and CBA mice, which permit definitive decisions regarding genetic and/or viral origin of the disease. It is proposed that at least two factors must be involved: a genetic abnormality producing hyper-responsiveness to nucleic acid antigens, and a DNA repair defect which results in liberation of DNA and RNA when cells are lethally injured. Evidence is presented for a DNA repair deficit in human SLE lymphocytes following in vitro irradiation with ultraviolet (uv) light. Lymphocytes from adult New Zealand and control mice were found to lack normal amounts of endonuclease necessary for repairing uv damage.}
journal = {J. Rheumatol.; (Canada)}
volume = {2:2}
journal type = {AC}
place = {Canada}
year = {1975}
month = {Jun}
}