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Some factors affecting urokinase inactivation. [Gamma radiation]

Journal Article:

Abstract

The enzymatic activity of urokinase adsorbed on various polymer surfaces was measured to study the interaction between protein and polymers. The polymer films on which urokinase was adsorbed were exposed to either a high temperature or ..gamma..-radiation. The thermal inactivation rates were higher on hydrophobic polymers such as poly(ethylene terephthalate), nylon 6, and poly(vinylidene fluoride) than hydrophilic polymers like cellulose and ethylene-vinyl alcohol copolymer, indicating their substantial dependence on the interfacial free energy between the polymer and water. A similar dependence was also seen for the ..gamma..-radiation inactivation. Urokinase adsorbed on the hydrophobic polymers lost more easily its enzymatic activity by exposure to ..gamma..-radiation. The interfacial free energy seems to be one of the driving forces to denaturate proteins on polymers.
Publication Date:
Oct 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-17-071868; EDB-87-003739
Resource Relation:
Journal Name: Kobunshi Ronbunshu; (Japan); Journal Volume: 42:10
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; PROTEINS; CHEMICAL RADIATION EFFECTS; UROKINASE; ADSORPTION; CATALYSIS; CELLULOSE; FILMS; FREE ENERGY; GAMMA RADIATION; HEAT TREATMENTS; INTERFACES; METABOLISM; NYLON; POLYESTERS; SURGICAL MATERIALS; CARBOHYDRATES; CHEMISTRY; DRUGS; ELECTROMAGNETIC RADIATION; ENERGY; ENZYMES; ESTERS; FIBRINOLYTIC AGENTS; HEMATOLOGIC AGENTS; HYDROLASES; IONIZING RADIATIONS; MATERIALS; MEDICAL SUPPLIES; NONSPECIFIC PEPTIDASES; ORGANIC COMPOUNDS; ORGANIC POLYMERS; PEPTIDE HYDROLASES; PETROCHEMICALS; PETROLEUM PRODUCTS; PHYSICAL PROPERTIES; PLASTICS; POLYAMIDES; POLYMERS; POLYSACCHARIDES; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; SACCHARIDES; SORPTION; SYNTHETIC MATERIALS; THERMODYNAMIC PROPERTIES; 400600* - Radiation Chemistry
OSTI ID:
7222382
Research Organizations:
Kyoto Univ., Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KBRBA
Submitting Site:
INIS
Size:
Pages: 699-703
Announcement Date:

Journal Article:

Citation Formats

Iwata, Hiroo, and Iketa, Yoshito. Some factors affecting urokinase inactivation. [Gamma radiation]. Japan: N. p., 1985. Web.
Iwata, Hiroo, & Iketa, Yoshito. Some factors affecting urokinase inactivation. [Gamma radiation]. Japan.
Iwata, Hiroo, and Iketa, Yoshito. 1985. "Some factors affecting urokinase inactivation. [Gamma radiation]." Japan.
@misc{etde_7222382,
title = {Some factors affecting urokinase inactivation. [Gamma radiation]}
author = {Iwata, Hiroo, and Iketa, Yoshito}
abstractNote = {The enzymatic activity of urokinase adsorbed on various polymer surfaces was measured to study the interaction between protein and polymers. The polymer films on which urokinase was adsorbed were exposed to either a high temperature or ..gamma..-radiation. The thermal inactivation rates were higher on hydrophobic polymers such as poly(ethylene terephthalate), nylon 6, and poly(vinylidene fluoride) than hydrophilic polymers like cellulose and ethylene-vinyl alcohol copolymer, indicating their substantial dependence on the interfacial free energy between the polymer and water. A similar dependence was also seen for the ..gamma..-radiation inactivation. Urokinase adsorbed on the hydrophobic polymers lost more easily its enzymatic activity by exposure to ..gamma..-radiation. The interfacial free energy seems to be one of the driving forces to denaturate proteins on polymers.}
journal = {Kobunshi Ronbunshu; (Japan)}
volume = {42:10}
journal type = {AC}
place = {Japan}
year = {1985}
month = {Oct}
}