You need JavaScript to view this

Radioprotective action of serotonin

Abstract

Tests in vitro were performed to study the effect of serotonin on oxidative phosphorylation in the mitochondria of rat liver. Serotonin (2.10/sup -4/ M) was shown to suppress oxidation of ..cap alpha..-ketoglutaric acid without significantly changing succinic acid consumption. A comparison of the results obtained with those from the literature allowed to assume that the radioprotective effect of serotonin was based not only on its previously known ability to cause tissue hypoxia, but also on its ability to affect oxidation processes in mitochondria.
Authors:
Vodop'yanova, L G; Vinogradova, M F [1] 
  1. Leningradskij Gosudarstvennyj Univ. (USSR). Biologicheskij Nauchno-Issledovatel'skij Inst.
Publication Date:
Sep 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-337544; EDB-77-148202
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 15:5; Other Information: For English translation see the journal Radiobiology
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SEROTONIN; RADIOSENSITIVITY EFFECTS; BIOLOGICAL EFFECTS; CHEMICAL REACTION KINETICS; IN VITRO; IRRADIATION; LIVER; MITOCHONDRIA; OXIDATION; PHOSPHORYLATION; RATS; AMINES; ANIMALS; AZOLES; BODY; CELL CONSTITUENTS; CHEMICAL REACTIONS; DIGESTIVE SYSTEM; DRUGS; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; KINETICS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANOIDS; ORGANS; PYRROLES; RADIOPROTECTIVE SUBSTANCES; REACTION KINETICS; RESPONSE MODIFYING FACTORS; RODENTS; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7214378
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 712-715
Announcement Date:
Oct 01, 1977

Citation Formats

Vodop'yanova, L G, and Vinogradova, M F. Radioprotective action of serotonin. USSR: N. p., 1975. Web.
Vodop'yanova, L G, & Vinogradova, M F. Radioprotective action of serotonin. USSR.
Vodop'yanova, L G, and Vinogradova, M F. 1975. "Radioprotective action of serotonin." USSR.
@misc{etde_7214378,
title = {Radioprotective action of serotonin}
author = {Vodop'yanova, L G, and Vinogradova, M F}
abstractNote = {Tests in vitro were performed to study the effect of serotonin on oxidative phosphorylation in the mitochondria of rat liver. Serotonin (2.10/sup -4/ M) was shown to suppress oxidation of ..cap alpha..-ketoglutaric acid without significantly changing succinic acid consumption. A comparison of the results obtained with those from the literature allowed to assume that the radioprotective effect of serotonin was based not only on its previously known ability to cause tissue hypoxia, but also on its ability to affect oxidation processes in mitochondria.}
journal = []
volume = {15:5}
journal type = {AC}
place = {USSR}
year = {1975}
month = {Sep}
}