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Calcium-antagonists and islet function. V. Effect of R33711

Journal Article:

Abstract

R33711, a new drug with presumed potent calcium-antagonistic property, was found to suppress the insulinotropic action of glucose und gliclazide but not that of theophylline. A 0.2 ..mu..M concentration of R33711 was sufficient to abolish glucose-induced insulin release. At this concentration, R33711 inhibited the net uptake of /sup 45/Ca/sup 2 +/ by isolated islets, whether in the absence or presence of either glucose or sulfonylurea. In the isolated islets, R33711 failed to affect the glucose-stimulated production of lactate, the rate of /sup 45/Ca/sup 2 +/ efflux, the inhibitory action of glucose upon such an efflux and its increase in response to theophylline. These data are compatible with the view that R33711 inhibits entry of Ca/sup 2 +/ into the B-cell and that integrity of such an inward cationic movement usually plays a permissive role in the maintenance of the Ca/sup 2 +/-dependent insulin secretory process.
Authors:
Malaisse, W J; Sener, A; Devis, G; Somers, G [1] 
  1. Brussels Univ. (Belgium). Lab. of Experimental Medicine
Publication Date:
Nov 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-306309; EDB-77-108725
Resource Relation:
Journal Name: Horm. Metab. Res.; (Germany, Federal Republic of); Journal Volume: 8:6; Other Information: 4 figs.; 3 tabs.; 19 refs
Subject:
59 BASIC BIOLOGICAL SCIENCES; CALCIUM 45; METABOLISM; CHEMICAL REACTIONS; DIAGNOSIS; INSULIN; PANCREAS; RATS; THEOPHYLLINE; THERAPY; TRACER TECHNIQUES; UREA; ALKALINE EARTH ISOTOPES; AMIDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; CARBONIC ACID DERIVATIVES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DIURETICS; DRUGS; ENDOCRINE GLANDS; EVEN-ODD NUCLEI; GLANDS; HETEROCYCLIC COMPOUNDS; HORMONES; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PEPTIDE HORMONES; PURINES; RADIOISOTOPES; RODENTS; VERTEBRATES; XANTHINES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
7212884
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HMMRA
Submitting Site:
INIS
Size:
Pages: 434-438
Announcement Date:
Aug 01, 1977

Journal Article:

Citation Formats

Malaisse, W J, Sener, A, Devis, G, and Somers, G. Calcium-antagonists and islet function. V. Effect of R33711. Germany: N. p., 1976. Web.
Malaisse, W J, Sener, A, Devis, G, & Somers, G. Calcium-antagonists and islet function. V. Effect of R33711. Germany.
Malaisse, W J, Sener, A, Devis, G, and Somers, G. 1976. "Calcium-antagonists and islet function. V. Effect of R33711." Germany.
@misc{etde_7212884,
title = {Calcium-antagonists and islet function. V. Effect of R33711}
author = {Malaisse, W J, Sener, A, Devis, G, and Somers, G}
abstractNote = {R33711, a new drug with presumed potent calcium-antagonistic property, was found to suppress the insulinotropic action of glucose und gliclazide but not that of theophylline. A 0.2 ..mu..M concentration of R33711 was sufficient to abolish glucose-induced insulin release. At this concentration, R33711 inhibited the net uptake of /sup 45/Ca/sup 2 +/ by isolated islets, whether in the absence or presence of either glucose or sulfonylurea. In the isolated islets, R33711 failed to affect the glucose-stimulated production of lactate, the rate of /sup 45/Ca/sup 2 +/ efflux, the inhibitory action of glucose upon such an efflux and its increase in response to theophylline. These data are compatible with the view that R33711 inhibits entry of Ca/sup 2 +/ into the B-cell and that integrity of such an inward cationic movement usually plays a permissive role in the maintenance of the Ca/sup 2 +/-dependent insulin secretory process.}
journal = {Horm. Metab. Res.; (Germany, Federal Republic of)}
volume = {8:6}
journal type = {AC}
place = {Germany}
year = {1976}
month = {Nov}
}