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Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts

Abstract

The capacity of whole cell sonicates of skin fibroblasts of normal individuals and patients with the autosomal recessive disease Ataxia telangiectasia (AT) to remove aerobic gamma-ray products of the 5,6-dihydroxydihydrothymine type (tsub(O/sub 2/)sup(..gamma..)) from exogenous DNA substrates was investigated. All four AT strains (AT CRL 1312, AT CRL 1343, AT GM 367, AT 4BI) possessed normal capabilities to excise tsub(O/sub 2/)sup(..gamma..) from irradiated bacteriophage DNA and irradiated chromatin isolated from normal and AT-skin fibroblasts.
Authors:
Remsen, J F; Cerutti, P A; [1]  Florida Univ., Gainesville (USA). Dept. of Biochemistry)
  1. Florida Univ., Gainesville (USA). Inst. of Food and Agricultural Sciences
Publication Date:
Apr 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-318268; EDB-77-115403
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 43:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL REPAIR; BACTERIOPHAGES; CESIUM 137; CHROMATIN; EXPERIMENTAL NEOPLASMS; FIBROBLASTS; GAMMA RADIATION; HOST-CELL REACTIVATION; MAN; SUBSTRATES; TELANGIECTASIS; THYMINE; ALKALI METAL ISOTOPES; ANIMAL CELLS; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; CARDIOVASCULAR DISEASES; CESIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; ISOTOPES; MAMMALS; MICROORGANISMS; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARASITES; PRIMATES; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RECOVERY; REPAIR; SOMATIC CELLS; URACILS; VERTEBRATES; VIRUSES; YEARS LIVING RADIOISOTOPES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7210856
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 139-146
Announcement Date:
Aug 01, 1977

Citation Formats

Remsen, J F, Cerutti, P A, and Florida Univ., Gainesville (USA). Dept. of Biochemistry). Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts. Netherlands: N. p., 1977. Web.
Remsen, J F, Cerutti, P A, & Florida Univ., Gainesville (USA). Dept. of Biochemistry). Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts. Netherlands.
Remsen, J F, Cerutti, P A, and Florida Univ., Gainesville (USA). Dept. of Biochemistry). 1977. "Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts." Netherlands.
@misc{etde_7210856,
title = {Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblasts}
author = {Remsen, J F, Cerutti, P A, and Florida Univ., Gainesville (USA). Dept. of Biochemistry)}
abstractNote = {The capacity of whole cell sonicates of skin fibroblasts of normal individuals and patients with the autosomal recessive disease Ataxia telangiectasia (AT) to remove aerobic gamma-ray products of the 5,6-dihydroxydihydrothymine type (tsub(O/sub 2/)sup(..gamma..)) from exogenous DNA substrates was investigated. All four AT strains (AT CRL 1312, AT CRL 1343, AT GM 367, AT 4BI) possessed normal capabilities to excise tsub(O/sub 2/)sup(..gamma..) from irradiated bacteriophage DNA and irradiated chromatin isolated from normal and AT-skin fibroblasts.}
journal = []
volume = {43:1}
journal type = {AC}
place = {Netherlands}
year = {1977}
month = {Apr}
}