Abstract
DNA repair defects as exhibited in fibroblasts from patients with xeroderma pigmentosa were studied. Five complementation groups for excision-repair defects were examined to test the hypothesis that a defective endonuclease or exonuclease may be the cause. No evidence was found to indicate that the enzyme activity functions in dimer excision. Since ultraviolet irradiated E. coli DNA incised with an endonuclease purified from phage-infected cells were used, it is possible that other factors may be involved in human UV endonuclease action. (JWP)
Citation Formats
Cook, K, Friedberg, E C, Slor, H, and Cleaver, J E.
Excision of thymine dimers from specifically incised DNA by extracts of xeroderma pigmentosum cells.
United Kingdom: N. p.,
1975.
Web.
doi:10.1038/256235a0.
Cook, K, Friedberg, E C, Slor, H, & Cleaver, J E.
Excision of thymine dimers from specifically incised DNA by extracts of xeroderma pigmentosum cells.
United Kingdom.
https://doi.org/10.1038/256235a0
Cook, K, Friedberg, E C, Slor, H, and Cleaver, J E.
1975.
"Excision of thymine dimers from specifically incised DNA by extracts of xeroderma pigmentosum cells."
United Kingdom.
https://doi.org/10.1038/256235a0.
@misc{etde_7195162,
title = {Excision of thymine dimers from specifically incised DNA by extracts of xeroderma pigmentosum cells}
author = {Cook, K, Friedberg, E C, Slor, H, and Cleaver, J E}
abstractNote = {DNA repair defects as exhibited in fibroblasts from patients with xeroderma pigmentosa were studied. Five complementation groups for excision-repair defects were examined to test the hypothesis that a defective endonuclease or exonuclease may be the cause. No evidence was found to indicate that the enzyme activity functions in dimer excision. Since ultraviolet irradiated E. coli DNA incised with an endonuclease purified from phage-infected cells were used, it is possible that other factors may be involved in human UV endonuclease action. (JWP)}
doi = {10.1038/256235a0}
journal = []
volume = {256:5514}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Jul}
}
title = {Excision of thymine dimers from specifically incised DNA by extracts of xeroderma pigmentosum cells}
author = {Cook, K, Friedberg, E C, Slor, H, and Cleaver, J E}
abstractNote = {DNA repair defects as exhibited in fibroblasts from patients with xeroderma pigmentosa were studied. Five complementation groups for excision-repair defects were examined to test the hypothesis that a defective endonuclease or exonuclease may be the cause. No evidence was found to indicate that the enzyme activity functions in dimer excision. Since ultraviolet irradiated E. coli DNA incised with an endonuclease purified from phage-infected cells were used, it is possible that other factors may be involved in human UV endonuclease action. (JWP)}
doi = {10.1038/256235a0}
journal = []
volume = {256:5514}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Jul}
}