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Pharmacokinetic studies on the hepatotoxicity of luteoskyrin, 1. Intracellular distribution of radioactivity in the liver of mice administered /sup 3/H-luteoskyrin

Abstract

Intracellular distribution of the radioactivity derived from /sup 3/H-luteoskyrin in mouse liver was investigated. It was revealed that luteoskyrin has a high affinity to mitochondria and cell debris of mouse liver cells. This characteristic distribution pattern in the liver cells may be responsible for the mitochondrial impairment and the age and sex differences in the susceptibility of mice to this mycotoxin. (auth)
Authors:
Ueno, I; [1]  Hayashi, T; Ueno, Y
  1. Tokyo Univ. (Japan). Inst. for Medical Science
Publication Date:
Aug 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-043694
Resource Relation:
Journal Name: Jpn. J. Pharmacol.; (Japan); Journal Volume: 24:4
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTHRAQUINONES; TOXICITY; DISTRIBUTION; LIVER; METABOLISM; MICE; PENICILLIUM; SUBCUTANEOUS INJECTION; TIME DEPENDENCE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AROMATICS; BIOMASS; BODY; DIGESTIVE SYSTEM; ENERGY SOURCES; FUNGI; GLANDS; INJECTION; INTAKE; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PLANTS; QUINONES; RENEWABLE ENERGY SOURCES; RODENTS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
7195133
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JJPAA
Submitting Site:
INIS
Size:
Pages: 535-542
Announcement Date:
Jun 01, 1976

Citation Formats

Ueno, I, Hayashi, T, and Ueno, Y. Pharmacokinetic studies on the hepatotoxicity of luteoskyrin, 1. Intracellular distribution of radioactivity in the liver of mice administered /sup 3/H-luteoskyrin. Japan: N. p., 1974. Web.
Ueno, I, Hayashi, T, & Ueno, Y. Pharmacokinetic studies on the hepatotoxicity of luteoskyrin, 1. Intracellular distribution of radioactivity in the liver of mice administered /sup 3/H-luteoskyrin. Japan.
Ueno, I, Hayashi, T, and Ueno, Y. 1974. "Pharmacokinetic studies on the hepatotoxicity of luteoskyrin, 1. Intracellular distribution of radioactivity in the liver of mice administered /sup 3/H-luteoskyrin." Japan.
@misc{etde_7195133,
title = {Pharmacokinetic studies on the hepatotoxicity of luteoskyrin, 1. Intracellular distribution of radioactivity in the liver of mice administered /sup 3/H-luteoskyrin}
author = {Ueno, I, Hayashi, T, and Ueno, Y}
abstractNote = {Intracellular distribution of the radioactivity derived from /sup 3/H-luteoskyrin in mouse liver was investigated. It was revealed that luteoskyrin has a high affinity to mitochondria and cell debris of mouse liver cells. This characteristic distribution pattern in the liver cells may be responsible for the mitochondrial impairment and the age and sex differences in the susceptibility of mice to this mycotoxin. (auth)}
journal = []
volume = {24:4}
journal type = {AC}
place = {Japan}
year = {1974}
month = {Aug}
}