Abstract
A 2.2 kb EcoRI-EcoRI fragment from the 5{prime} end of the human amyloid beta protein cDNA was isolated from a human fibroblast cDNA library and subcloned into pGEM3. HaeIII (GGCC) detects 6 invariant bands at 0.5 kb, 1.0 kb, 1.1 kb, 1.3 kb, 1.4 kb and 1.6 kb and a two-allele polymorphism with bands at either 1.9 kb or 2.1 kb. Its frequency was studied in 50 North Americans. Human amyloid beta protein gene mapped to the long arm of chromosome 21 (21q11.2-21q21) by Southern blot analysis of human-rodent somatic cell hybrids. Co-dominant segregation was observed in two families (15 individuals).
Taylor, J E;
Gonzalez-DeWhitt, P A;
Fuller, F;
Cordell, B;
Frossard, P M;
[1]
Tinklenberg, J R;
Davies, H D;
Eng, L F;
Yesavage, J A
[2]
- California Biotechnology Inc., Mountain View (USA)
- Stanford Univ. School of Medicine, Palo Alto, CA (USA)
Citation Formats
Taylor, J E, Gonzalez-DeWhitt, P A, Fuller, F, Cordell, B, Frossard, P M, Tinklenberg, J R, Davies, H D, Eng, L F, and Yesavage, J A.
Human amyloid beta protein gene locus: HaeIII RFLP.
United Kingdom: N. p.,
1988.
Web.
doi:10.1093/nar/16.14.7217.
Taylor, J E, Gonzalez-DeWhitt, P A, Fuller, F, Cordell, B, Frossard, P M, Tinklenberg, J R, Davies, H D, Eng, L F, & Yesavage, J A.
Human amyloid beta protein gene locus: HaeIII RFLP.
United Kingdom.
https://doi.org/10.1093/nar/16.14.7217
Taylor, J E, Gonzalez-DeWhitt, P A, Fuller, F, Cordell, B, Frossard, P M, Tinklenberg, J R, Davies, H D, Eng, L F, and Yesavage, J A.
1988.
"Human amyloid beta protein gene locus: HaeIII RFLP."
United Kingdom.
https://doi.org/10.1093/nar/16.14.7217.
@misc{etde_7193252,
title = {Human amyloid beta protein gene locus: HaeIII RFLP}
author = {Taylor, J E, Gonzalez-DeWhitt, P A, Fuller, F, Cordell, B, Frossard, P M, Tinklenberg, J R, Davies, H D, Eng, L F, and Yesavage, J A}
abstractNote = {A 2.2 kb EcoRI-EcoRI fragment from the 5{prime} end of the human amyloid beta protein cDNA was isolated from a human fibroblast cDNA library and subcloned into pGEM3. HaeIII (GGCC) detects 6 invariant bands at 0.5 kb, 1.0 kb, 1.1 kb, 1.3 kb, 1.4 kb and 1.6 kb and a two-allele polymorphism with bands at either 1.9 kb or 2.1 kb. Its frequency was studied in 50 North Americans. Human amyloid beta protein gene mapped to the long arm of chromosome 21 (21q11.2-21q21) by Southern blot analysis of human-rodent somatic cell hybrids. Co-dominant segregation was observed in two families (15 individuals).}
doi = {10.1093/nar/16.14.7217}
journal = []
volume = {16:14B}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jul}
}
title = {Human amyloid beta protein gene locus: HaeIII RFLP}
author = {Taylor, J E, Gonzalez-DeWhitt, P A, Fuller, F, Cordell, B, Frossard, P M, Tinklenberg, J R, Davies, H D, Eng, L F, and Yesavage, J A}
abstractNote = {A 2.2 kb EcoRI-EcoRI fragment from the 5{prime} end of the human amyloid beta protein cDNA was isolated from a human fibroblast cDNA library and subcloned into pGEM3. HaeIII (GGCC) detects 6 invariant bands at 0.5 kb, 1.0 kb, 1.1 kb, 1.3 kb, 1.4 kb and 1.6 kb and a two-allele polymorphism with bands at either 1.9 kb or 2.1 kb. Its frequency was studied in 50 North Americans. Human amyloid beta protein gene mapped to the long arm of chromosome 21 (21q11.2-21q21) by Southern blot analysis of human-rodent somatic cell hybrids. Co-dominant segregation was observed in two families (15 individuals).}
doi = {10.1093/nar/16.14.7217}
journal = []
volume = {16:14B}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jul}
}