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Blood coagulation in lead poisoning and the influence of specific treatment

Abstract

Results of blood coagulation studies in 104 workers with long-term exposure in a storage-battery plant. Over-all coagulation activity is unchanged in cases of mild lead poisoning, but long-term exposure gives rise to increased fibrinogen levels, activated fibrinolysis, and reduced serum accelerator globulin and prothrombin activities. 13 workers were given D-penicillamine (oral doses of 450 mg daily). All coagulation indices had become normal after 10 days' treatment. The changes observed are thought to be due to protein synthesis disturbances in the liver and to inhibition of enzymes by lead which combines with their sulfhydryl and disulfide groups. (CIS Abstr. Vol. 2)
Publication Date:
Jul 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-050247
Resource Relation:
Journal Name: Gig. Tr. Prof. Zabol.; (USSR); Journal Volume: 7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD COAGULATION; LEAD; BIOLOGICAL EFFECTS; CHRONIC INTAKE; FIBRINOGEN; FIBRINOLYSIS; GLOBULINS; MAN; PENICILLAMINE; PROTHROMBIN; THERAPY; TOXICITY; AMINO ACIDS; ANIMALS; BLOOD COAGULATION FACTORS; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; ELEMENTS; INTAKE; MAMMALS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; PROTEINS; PROTEOLYSIS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; THIOLS; VERTEBRATES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
7192974
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: GTPZA
Submitting Site:
TIC
Size:
Pages: 28-31
Announcement Date:
Jul 01, 1976

Citation Formats

Levantovskaya, O M, Lyubcenko, P N, Dayhin, I S, and Sorkina, N S. Blood coagulation in lead poisoning and the influence of specific treatment. USSR: N. p., 1974. Web.
Levantovskaya, O M, Lyubcenko, P N, Dayhin, I S, & Sorkina, N S. Blood coagulation in lead poisoning and the influence of specific treatment. USSR.
Levantovskaya, O M, Lyubcenko, P N, Dayhin, I S, and Sorkina, N S. 1974. "Blood coagulation in lead poisoning and the influence of specific treatment." USSR.
@misc{etde_7192974,
title = {Blood coagulation in lead poisoning and the influence of specific treatment}
author = {Levantovskaya, O M, Lyubcenko, P N, Dayhin, I S, and Sorkina, N S}
abstractNote = {Results of blood coagulation studies in 104 workers with long-term exposure in a storage-battery plant. Over-all coagulation activity is unchanged in cases of mild lead poisoning, but long-term exposure gives rise to increased fibrinogen levels, activated fibrinolysis, and reduced serum accelerator globulin and prothrombin activities. 13 workers were given D-penicillamine (oral doses of 450 mg daily). All coagulation indices had become normal after 10 days' treatment. The changes observed are thought to be due to protein synthesis disturbances in the liver and to inhibition of enzymes by lead which combines with their sulfhydryl and disulfide groups. (CIS Abstr. Vol. 2)}
journal = []
volume = {7}
journal type = {AC}
place = {USSR}
year = {1974}
month = {Jul}
}