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Contribution of positron emission tomography to physiopathological study of cerebral ischemia in man

Abstract

The development of positron emission tomography now allows the local study of cerebral blood flow, oxygen consumption and glucose utilization in ischemic stroke patients. In recent cerebral infarction, a disruption of the normal couple between flow and metabolism is almost constantly observed: in the first few days cerebral blood flow is either inadequate (persistant ischemia) or over-abundant (''luxury perfusion''), whereas a late ''luxury perfusion'' is almost constant within the necrotic area between the 10th and the 40th day. Threshold values for cerebral blood flow and oxygen consumption that are ultimately associated with necrosis or tissue integrity have been determined. A metabolic depression without C.T. Scan counterpart has been observed in various brain structures remote from the infarcted area per se. Lastly, the hemodynamic and metabolic effects of superficial-temporal-middle-cerebral-artery anastomosis have been studied.
Authors:
Baron, J C; Bousser, M G; Comar, D; Rougemont, D; Lebrun-Grandie, P; [1]  Castaigne, P [2] 
  1. Commissariat a l'Energie Atomique, Centre Hospitalier Frederic Joliot, 91 - Orsay (France)
  2. Hopital de la Salpetriere, 75 - Paris (France)
Publication Date:
Dec 29, 1983
Product Type:
Conference
Report Number:
CONF-821282-
Reference Number:
FR-84-00892; EDB-84-094813
Resource Relation:
Journal Name: Presse Med.; (France); Journal Volume: 12:48; Conference: International symposium on cerebral vascular pathology and pathology of the ageing brain, Monte-Carlo, Monaco, 3 Dec 1982
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; ISCHEMIA; POSITRON COMPUTED TOMOGRAPHY; CARBON 11; DIAGNOSTIC USES; FLUORINE 18; DIAGNOSIS; NITROGEN 13; OXYGEN 15; BLOOD FLOW; NECROSIS; RADIOPHARMACEUTICALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANS; OXYGEN ISOTOPES; PATHOLOGICAL CHANGES; RADIOISOTOPES; TOMOGRAPHY; USES; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7191664
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: PRMEA
Submitting Site:
HEDB
Size:
Pages: 3066-3072
Announcement Date:
May 01, 1984

Citation Formats

Baron, J C, Bousser, M G, Comar, D, Rougemont, D, Lebrun-Grandie, P, and Castaigne, P. Contribution of positron emission tomography to physiopathological study of cerebral ischemia in man. France: N. p., 1983. Web.
Baron, J C, Bousser, M G, Comar, D, Rougemont, D, Lebrun-Grandie, P, & Castaigne, P. Contribution of positron emission tomography to physiopathological study of cerebral ischemia in man. France.
Baron, J C, Bousser, M G, Comar, D, Rougemont, D, Lebrun-Grandie, P, and Castaigne, P. 1983. "Contribution of positron emission tomography to physiopathological study of cerebral ischemia in man." France.
@misc{etde_7191664,
title = {Contribution of positron emission tomography to physiopathological study of cerebral ischemia in man}
author = {Baron, J C, Bousser, M G, Comar, D, Rougemont, D, Lebrun-Grandie, P, and Castaigne, P}
abstractNote = {The development of positron emission tomography now allows the local study of cerebral blood flow, oxygen consumption and glucose utilization in ischemic stroke patients. In recent cerebral infarction, a disruption of the normal couple between flow and metabolism is almost constantly observed: in the first few days cerebral blood flow is either inadequate (persistant ischemia) or over-abundant (''luxury perfusion''), whereas a late ''luxury perfusion'' is almost constant within the necrotic area between the 10th and the 40th day. Threshold values for cerebral blood flow and oxygen consumption that are ultimately associated with necrosis or tissue integrity have been determined. A metabolic depression without C.T. Scan counterpart has been observed in various brain structures remote from the infarcted area per se. Lastly, the hemodynamic and metabolic effects of superficial-temporal-middle-cerebral-artery anastomosis have been studied.}
journal = []
volume = {12:48}
place = {France}
year = {1983}
month = {Dec}
}