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Radioprotection by murine and human tumor-necrosis factor; Dose-dependent effects on hematopoiesis in the mouse

Journal Article:

Abstract

Tumor-necrosis factor (TNF) has been shown to confer significant radioprotection in murine models. Herein, we demonstrate a dose-dependent enhancement of hematological recovery when single doses of either murine or human recombinant TNF are administered prior to irradiation. In addition to its action upon leukocytes and erythocytes, TNF also alleviates radiation-induced thrombocytopenia in the mouse. These effects on circulating blood constituents are further reflected in increased numbers of both primitive (CFU-S) and more differentiated (CFU-GM, CFU-Mega) hematopoietic progenitors in TNF-treated animals. This suggests that TNF exerts it radioprotective effects on a pool of primitive multi-potential hematopoietic cells. (author).
Authors:
Sloerdal, L; Muench, M O; Warren, D J; Moore, M A.S. [1] 
  1. James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York (USA)
Publication Date:
Jan 01, 1989
Product Type:
Journal Article
Reference Number:
AIX-21-049386; EDB-90-097320
Resource Relation:
Journal Name: European Journal of Haematology; (Denmark); Journal Volume: 43
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NECROSIS; RADIOPROTECTIVE SUBSTANCES; BLOOD FORMATION; CELL KILLING; DOSE-RESPONSE RELATIONSHIPS; ENDOTOXINS; MICE; NEOPLASMS; SUBLETHAL IRRADIATION; WHOLE-BODY IRRADIATION; ANIMALS; ANTIGENS; DISEASES; DRUGS; EXTERNAL IRRADIATION; IRRADIATION; MAMMALS; MATERIALS; PATHOLOGICAL CHANGES; RODENTS; TOXIC MATERIALS; TOXINS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560151 - Radiation Effects on Animals- Man
OSTI ID:
7190804
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0902-4441; CODEN: EJHAE
Submitting Site:
DKN
Size:
Pages: 43
Announcement Date:

Journal Article:

Citation Formats

Sloerdal, L, Muench, M O, Warren, D J, and Moore, M A.S. Radioprotection by murine and human tumor-necrosis factor; Dose-dependent effects on hematopoiesis in the mouse. Denmark: N. p., 1989. Web.
Sloerdal, L, Muench, M O, Warren, D J, & Moore, M A.S. Radioprotection by murine and human tumor-necrosis factor; Dose-dependent effects on hematopoiesis in the mouse. Denmark.
Sloerdal, L, Muench, M O, Warren, D J, and Moore, M A.S. 1989. "Radioprotection by murine and human tumor-necrosis factor; Dose-dependent effects on hematopoiesis in the mouse." Denmark.
@misc{etde_7190804,
title = {Radioprotection by murine and human tumor-necrosis factor; Dose-dependent effects on hematopoiesis in the mouse}
author = {Sloerdal, L, Muench, M O, Warren, D J, and Moore, M A.S.}
abstractNote = {Tumor-necrosis factor (TNF) has been shown to confer significant radioprotection in murine models. Herein, we demonstrate a dose-dependent enhancement of hematological recovery when single doses of either murine or human recombinant TNF are administered prior to irradiation. In addition to its action upon leukocytes and erythocytes, TNF also alleviates radiation-induced thrombocytopenia in the mouse. These effects on circulating blood constituents are further reflected in increased numbers of both primitive (CFU-S) and more differentiated (CFU-GM, CFU-Mega) hematopoietic progenitors in TNF-treated animals. This suggests that TNF exerts it radioprotective effects on a pool of primitive multi-potential hematopoietic cells. (author).}
journal = {European Journal of Haematology; (Denmark)}
volume = {43}
journal type = {AC}
place = {Denmark}
year = {1989}
month = {Jan}
}