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Respiration and phosphorylation in liver and kidney mitochondria of rats exposed to high-energy gamma and beta radiation

Journal Article:

Abstract

The effect of whole-body irradiation with ..gamma.. rays (radiation source /sup 60/Co) at 40 rad and ..beta.. rays (source, a linear accelerator, electron energy 25 MeV) at 43 rad on oxidative phosphorylation in liver and kidney mitochondria was studied in rats. Gamma radiation gradually slowed the esterification of phosphate and respiratory rate during the oxidation of succinate in the liver and kidney mitochondria. The decrease was largest on day 15 after irradiation. However, the P/O ratio did not decrease by more than 10 to 12 percent. Despite the oxidation of glutamate in the mitochondria, respiration, phosphate consumption, and P/O ratio scarcely changed. Irradiation with electrons slowed the rate of oxidation of succinate and glutamate in liver mitochondria within 3 to 7 days. Phosphate consumption decreased at the same time so that the P/O ratio remained unchanged. Beta irradiation had virtually no effect on liver mitochondria. There is a discussion of the mechanism of action of high-energy radiation on the phosphorylation system of the mitochondria.
Publication Date:
Jan 01, 1973
Product Type:
Journal Article
Reference Number:
EDB-76-055783
Resource Relation:
Journal Name: Aktual. Probl. Onkol. Med. Radiol.; (Byelorussian SSR); Journal Volume: 3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MITOCHONDRIA; BIOLOGICAL RADIATION EFFECTS; PHOSPHORYLATION; RESPIRATION; BETA PARTICLES; COBALT 60; COMPARATIVE EVALUATIONS; GAMMA RADIATION; KIDNEYS; LIVER; MEV RANGE 10-100; RATS; WHOLE-BODY IRRADIATION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CELL CONSTITUENTS; CHARGED PARTICLES; CHEMICAL REACTIONS; COBALT ISOTOPES; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ENERGY RANGE; EXTERNAL IRRADIATION; GLANDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEV RANGE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANOIDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7190251
Country of Origin:
Belarus
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: APORD
Submitting Site:
HEDB
Size:
Pages: 364-367
Announcement Date:
Aug 01, 1976

Journal Article:

Citation Formats

Mokhoreva, S I, and Vetlugina, N S. Respiration and phosphorylation in liver and kidney mitochondria of rats exposed to high-energy gamma and beta radiation. Belarus: N. p., 1973. Web.
Mokhoreva, S I, & Vetlugina, N S. Respiration and phosphorylation in liver and kidney mitochondria of rats exposed to high-energy gamma and beta radiation. Belarus.
Mokhoreva, S I, and Vetlugina, N S. 1973. "Respiration and phosphorylation in liver and kidney mitochondria of rats exposed to high-energy gamma and beta radiation." Belarus.
@misc{etde_7190251,
title = {Respiration and phosphorylation in liver and kidney mitochondria of rats exposed to high-energy gamma and beta radiation}
author = {Mokhoreva, S I, and Vetlugina, N S}
abstractNote = {The effect of whole-body irradiation with ..gamma.. rays (radiation source /sup 60/Co) at 40 rad and ..beta.. rays (source, a linear accelerator, electron energy 25 MeV) at 43 rad on oxidative phosphorylation in liver and kidney mitochondria was studied in rats. Gamma radiation gradually slowed the esterification of phosphate and respiratory rate during the oxidation of succinate in the liver and kidney mitochondria. The decrease was largest on day 15 after irradiation. However, the P/O ratio did not decrease by more than 10 to 12 percent. Despite the oxidation of glutamate in the mitochondria, respiration, phosphate consumption, and P/O ratio scarcely changed. Irradiation with electrons slowed the rate of oxidation of succinate and glutamate in liver mitochondria within 3 to 7 days. Phosphate consumption decreased at the same time so that the P/O ratio remained unchanged. Beta irradiation had virtually no effect on liver mitochondria. There is a discussion of the mechanism of action of high-energy radiation on the phosphorylation system of the mitochondria.}
journal = {Aktual. Probl. Onkol. Med. Radiol.; (Byelorussian SSR)}
volume = {3}
journal type = {AC}
place = {Belarus}
year = {1973}
month = {Jan}
}