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Sex-related differences in NADPH-dependent lipid peroxidation induced by cadmium

Journal Article:

Abstract

Male and female rats were dosed once a day for 2 days with injections of 1.5 mg Cd/kg. Formation of thiobarbituric acid reactive substances (TBA-RS) was significantly increased in male rat liver but not in the females. NADPH-dependent lipid peroxidation in vitro in microsomes derived from untreated rat liver was greater in males than in females. Furthermore, addition of cadmium (Cd) to microsomes isolated from male rat liver produced a dose-dependent potentiation of NADPH-dependent lipid peroxidation from low concentrations of CD. In microsomes derived from females a significant increase in lipid peroxidation was observed only at high Cd concentrations. NADPH-dependent lipid peroxidation enhanced by Cd was greater in the males than in the females. These data suggest that a sex-related difference in the ability of Cd to induce lipid peroxidation in vivo in rat liver appears to be mediated partly through differences in hepatic microsomal NADPH-dependent lipid peroxidation.
Publication Date:
Oct 01, 1986
Product Type:
Journal Article
Reference Number:
DE-87-000092; EDB-87-018336
Resource Relation:
Journal Name: Arch. Toxikol.; (Germany, Federal Republic of); Journal Volume: 59:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; BIOLOGICAL EFFECTS; METABOLISM; MICROSOMES; FEMALES; IN VITRO; IN VIVO; INJECTION; LIPIDS; LIVER; MALES; NADP; PEROXIDES; RATS; SEX DEPENDENCE; ANIMALS; BODY; CELL CONSTITUENTS; COENZYMES; DIGESTIVE SYSTEM; ELEMENTS; GLANDS; INTAKE; MAMMALS; METALS; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; OXYGEN COMPOUNDS; RODENTS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
OSTI ID:
7187081
Research Organizations:
Fukushima Medical Coll., Japan. Div. of Environmental Pollution Research
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ATXKA
Submitting Site:
DE
Size:
Pages: 156-159
Announcement Date:

Journal Article:

Citation Formats

Sato, Masao, and Nagai, Yasushi. Sex-related differences in NADPH-dependent lipid peroxidation induced by cadmium. Germany: N. p., 1986. Web.
Sato, Masao, & Nagai, Yasushi. Sex-related differences in NADPH-dependent lipid peroxidation induced by cadmium. Germany.
Sato, Masao, and Nagai, Yasushi. 1986. "Sex-related differences in NADPH-dependent lipid peroxidation induced by cadmium." Germany.
@misc{etde_7187081,
title = {Sex-related differences in NADPH-dependent lipid peroxidation induced by cadmium}
author = {Sato, Masao, and Nagai, Yasushi}
abstractNote = {Male and female rats were dosed once a day for 2 days with injections of 1.5 mg Cd/kg. Formation of thiobarbituric acid reactive substances (TBA-RS) was significantly increased in male rat liver but not in the females. NADPH-dependent lipid peroxidation in vitro in microsomes derived from untreated rat liver was greater in males than in females. Furthermore, addition of cadmium (Cd) to microsomes isolated from male rat liver produced a dose-dependent potentiation of NADPH-dependent lipid peroxidation from low concentrations of CD. In microsomes derived from females a significant increase in lipid peroxidation was observed only at high Cd concentrations. NADPH-dependent lipid peroxidation enhanced by Cd was greater in the males than in the females. These data suggest that a sex-related difference in the ability of Cd to induce lipid peroxidation in vivo in rat liver appears to be mediated partly through differences in hepatic microsomal NADPH-dependent lipid peroxidation.}
journal = {Arch. Toxikol.; (Germany, Federal Republic of)}
volume = {59:3}
journal type = {AC}
place = {Germany}
year = {1986}
month = {Oct}
}