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Modulation of intestinal absorption of calcium

Journal Article:

Abstract

Absorption of ingested calcium (2ml of a 10mM CaCl/sub 2/ solution + /sup 45/Ca) by the adult rat was shown to be facilitated by the simultaneous ingestion of an active carbohydrate, L-arabinose. As the carbohydrate concentration is increased from 10 to 200mM, the absorption of calcium is maximised at a level corresponding to about twice the control absorption level. A similar doubling of calcium absorption is obtained when a 100mM concentration of any one of a number of other carbohydrates is ingested simultaneously with a 10mM CaCl/sub 2/ solution. Conversely, the simultaneous ingestion of increasing doses (10 to 100mM) of phosphate (NaH/sub 2/PO/sub 4/) with a 10mM CaCl/sub 2/ solution results in decreased /sup 45/Ca absorption and retention by the adult rat. The maximum inhibition of calcium absorption by phosphate is independent of the concentration of the ingested calcium solution (from 5 to 50mM CaCl/sub 2/). The simultaneous ingestion of CaCl/sub 2/ (10mM) with lactose and sodium phosphate (50 and 10mM respectively) shows that the activation effect of lactose upon /sup 45/Ca absorption may be partly dissimulated by the presence of phosphate. These various observations indicate that, within a large concentration range (2 to 50mM CaCl/sub 2/) calcium absorption appears  More>>
Authors:
Fournier, P; Dupuis, Y; [1]  Paris-11 Univ., 92 - Chatenay-Malabry (France))
  1. Ecole Pratique des Hautes Etudes, 75 - Paris (France)
Publication Date:
Jan 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-246011; EDB-76-072593
Resource Relation:
Journal Name: J. Physiol. (Paris); (France); Journal Volume: 70:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CALCIUM 45; INTESTINAL ABSORPTION; CALCIUM; PHOSPHATES; RATS; RETENTION; SACCHARIDES; TRACER TECHNIQUES; ALKALINE EARTH ISOTOPES; ALKALINE EARTH METALS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CALCIUM ISOTOPES; CARBOHYDRATES; DAYS LIVING RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METALS; NUCLEI; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOISOTOPES; RODENTS; UPTAKE; VERTEBRATES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
7181763
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: JOPHA
Submitting Site:
INIS
Size:
Pages: 479-491
Announcement Date:

Journal Article:

Citation Formats

Fournier, P, Dupuis, Y, and Paris-11 Univ., 92 - Chatenay-Malabry (France)). Modulation of intestinal absorption of calcium. France: N. p., 1975. Web.
Fournier, P, Dupuis, Y, & Paris-11 Univ., 92 - Chatenay-Malabry (France)). Modulation of intestinal absorption of calcium. France.
Fournier, P, Dupuis, Y, and Paris-11 Univ., 92 - Chatenay-Malabry (France)). 1975. "Modulation of intestinal absorption of calcium." France.
@misc{etde_7181763,
title = {Modulation of intestinal absorption of calcium}
author = {Fournier, P, Dupuis, Y, and Paris-11 Univ., 92 - Chatenay-Malabry (France))}
abstractNote = {Absorption of ingested calcium (2ml of a 10mM CaCl/sub 2/ solution + /sup 45/Ca) by the adult rat was shown to be facilitated by the simultaneous ingestion of an active carbohydrate, L-arabinose. As the carbohydrate concentration is increased from 10 to 200mM, the absorption of calcium is maximised at a level corresponding to about twice the control absorption level. A similar doubling of calcium absorption is obtained when a 100mM concentration of any one of a number of other carbohydrates is ingested simultaneously with a 10mM CaCl/sub 2/ solution. Conversely, the simultaneous ingestion of increasing doses (10 to 100mM) of phosphate (NaH/sub 2/PO/sub 4/) with a 10mM CaCl/sub 2/ solution results in decreased /sup 45/Ca absorption and retention by the adult rat. The maximum inhibition of calcium absorption by phosphate is independent of the concentration of the ingested calcium solution (from 5 to 50mM CaCl/sub 2/). The simultaneous ingestion of CaCl/sub 2/ (10mM) with lactose and sodium phosphate (50 and 10mM respectively) shows that the activation effect of lactose upon /sup 45/Ca absorption may be partly dissimulated by the presence of phosphate. These various observations indicate that, within a large concentration range (2 to 50mM CaCl/sub 2/) calcium absorption appears to be a precisely modulated diffusion process. Calcium absorption varies (between minimum and maximum levels) as a function of the state of saturation by the activators (carbohydrates) and inhibitors (phosphate) of the calcium transport system.}
journal = {J. Physiol. (Paris); (France)}
volume = {70:4}
journal type = {AC}
place = {France}
year = {1975}
month = {Jan}
}