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Changes in ultrastructure of rat ovaries after early postnatal x-ray irradiation

Journal Article:

Abstract

Female rats were irradiated with 190R of X-rays at 10 days of age and the ovarian ultrastructures were studied 4 and 7 months after irradiation. Ultrastructural changes were found in germinal epithelial cells, in fibroblasts in the tunica albuginea and in interstitial cells. The germinal epithelial cells exhibited various signs of degeneration but no sign of proliferation. Electron density of their basal part was reduced considerably. Their mitochondria became swollen and free ribosomes were decreased in number. The nuclei often protruded from the free surface of these cells. These cells frequently fragmented and, finally, complete desquamation occurred. The basement membrane became unevently thickened. Nuclei of enlarged fibroblasts in the tunica albuginea became irregularly ellipsoid in shape, and the nuclear envelope was occasionally invaginated. Various cytoplasmic organelles of the fibroblasts were well-developed. Some abnormal invasion of cytoplasm into the nucleus was found in the interstitial cells showing the ultrastructural characteristics of steroid hormone synthesis. Various cytoplasmic roganelles and inclusions invaded into the nuclei of these cells and the nuclear envelope sometimes disappeared locally. These interstitial cells contained a large number of irregular-shaped electron dense mitochondria with vesicular cristae, and numerous dilated vesicles of smooth-surfaced endoplasmic reticulum (SER). The cells of the  More>>
Authors:
Matsumoto, A [1] 
  1. Juntendo Univ., Tokyo (Japan). School of Medicine
Publication Date:
Feb 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-244370; EDB-76-076976
Resource Relation:
Journal Name: Endocrinol. Jpn.; (Japan); Journal Volume: 22:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OVARIES; ULTRASTRUCTURAL CHANGES; BIOLOGICAL RADIATION EFFECTS; ELECTRON MICROSCOPY; FIBROBLASTS; INFANTS; IRRADIATION; OOCYTES; RATS; TIME DEPENDENCE; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHILDREN; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; FEMALE GENITALS; GERM CELLS; GONADS; IONIZING RADIATIONS; MAMMALS; MAN; MICROSCOPY; MORPHOLOGICAL CHANGES; NEONATES; ORGANS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7179016
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ECJPA
Submitting Site:
INIS
Size:
Pages: 1-15
Announcement Date:

Journal Article:

Citation Formats

Matsumoto, A. Changes in ultrastructure of rat ovaries after early postnatal x-ray irradiation. Japan: N. p., 1975. Web.
Matsumoto, A. Changes in ultrastructure of rat ovaries after early postnatal x-ray irradiation. Japan.
Matsumoto, A. 1975. "Changes in ultrastructure of rat ovaries after early postnatal x-ray irradiation." Japan.
@misc{etde_7179016,
title = {Changes in ultrastructure of rat ovaries after early postnatal x-ray irradiation}
author = {Matsumoto, A}
abstractNote = {Female rats were irradiated with 190R of X-rays at 10 days of age and the ovarian ultrastructures were studied 4 and 7 months after irradiation. Ultrastructural changes were found in germinal epithelial cells, in fibroblasts in the tunica albuginea and in interstitial cells. The germinal epithelial cells exhibited various signs of degeneration but no sign of proliferation. Electron density of their basal part was reduced considerably. Their mitochondria became swollen and free ribosomes were decreased in number. The nuclei often protruded from the free surface of these cells. These cells frequently fragmented and, finally, complete desquamation occurred. The basement membrane became unevently thickened. Nuclei of enlarged fibroblasts in the tunica albuginea became irregularly ellipsoid in shape, and the nuclear envelope was occasionally invaginated. Various cytoplasmic organelles of the fibroblasts were well-developed. Some abnormal invasion of cytoplasm into the nucleus was found in the interstitial cells showing the ultrastructural characteristics of steroid hormone synthesis. Various cytoplasmic roganelles and inclusions invaded into the nuclei of these cells and the nuclear envelope sometimes disappeared locally. These interstitial cells contained a large number of irregular-shaped electron dense mitochondria with vesicular cristae, and numerous dilated vesicles of smooth-surfaced endoplasmic reticulum (SER). The cells of the anovular follicles in the irradiated ovaries resembled, in fine structure, the granulosa cells in normal primary follicles of non-irradiated ovaries. These cells seemed to be less affected by early postnatal irradiation.}
journal = {Endocrinol. Jpn.; (Japan)}
volume = {22:1}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Feb}
}