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Late effects of X-irradiation in patients treated for metropathia haemorrhagica

Journal Article:

Abstract

The causes of death among 2,068 patients treated with X-irradiation for metropathia haemorrhagica at three Scottish radiotherapy centres between 1940 and 1960 have previously been reported. (Dol, R., and Smith, P.G., 1968, Br. J. Radiol., vol. 41, 362). This cohort of women has now been followed up for a further seven years. 500 (24 per cent) women have now died, 78 (3.8 per cent) have emigrated and 25 (1.2 per cent) could not be traced. The numbers of deaths from different causes have been compared with the numbers expected in a population of similar age and sex exposed to the Scottish national mortality rates over the same period. An excess of deaths from leukaemia (7 observed, 2.3 expected) and of cancers of the heavily irradiated sites (59 observed, 40.1 expected) continues to be observed five or more years after treatment. There is no indication of any change in the excess death rate, due to cancers of sites in the radiation field, with time since treatment up to at least 20 years after the radiation exposure. Over the same period the number of deaths from cancer of the breast was below expectation (10 observed, 22.3 expected) and no increased mortality from  More>>
Authors:
Smith, P G; Doll, R [1] 
  1. Department of Health and Social Security, Cancer Epidemiology and Clinical Trials Unit, 9 Keble Road, Oxford (UK)
Publication Date:
Mar 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-07-248519; EDB-76-082664
Resource Relation:
Journal Name: Br. J. Radiol.; (United Kingdom); Journal Volume: 49:579
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PATIENTS; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; X RADIATION; LEUKEMOGENESIS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARCINOGENESIS; DISEASES; ELECTROMAGNETIC RADIATION; FEMALE GENITALS; FEMALES; GLANDS; GONADS; HAZARDS; HEALTH HAZARDS; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; MAMMALS; MAN; MATHEMATICS; MEDICINE; NUCLEAR MEDICINE; ORGANS; PATHOGENESIS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; THERAPY; TISSUES; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7175862
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJRAA
Submitting Site:
INIS
Size:
Pages: 224-232
Announcement Date:
Aug 01, 1976

Journal Article:

Citation Formats

Smith, P G, and Doll, R. Late effects of X-irradiation in patients treated for metropathia haemorrhagica. United Kingdom: N. p., 1976. Web.
Smith, P G, & Doll, R. Late effects of X-irradiation in patients treated for metropathia haemorrhagica. United Kingdom.
Smith, P G, and Doll, R. 1976. "Late effects of X-irradiation in patients treated for metropathia haemorrhagica." United Kingdom.
@misc{etde_7175862,
title = {Late effects of X-irradiation in patients treated for metropathia haemorrhagica}
author = {Smith, P G, and Doll, R}
abstractNote = {The causes of death among 2,068 patients treated with X-irradiation for metropathia haemorrhagica at three Scottish radiotherapy centres between 1940 and 1960 have previously been reported. (Dol, R., and Smith, P.G., 1968, Br. J. Radiol., vol. 41, 362). This cohort of women has now been followed up for a further seven years. 500 (24 per cent) women have now died, 78 (3.8 per cent) have emigrated and 25 (1.2 per cent) could not be traced. The numbers of deaths from different causes have been compared with the numbers expected in a population of similar age and sex exposed to the Scottish national mortality rates over the same period. An excess of deaths from leukaemia (7 observed, 2.3 expected) and of cancers of the heavily irradiated sites (59 observed, 40.1 expected) continues to be observed five or more years after treatment. There is no indication of any change in the excess death rate, due to cancers of sites in the radiation field, with time since treatment up to at least 20 years after the radiation exposure. Over the same period the number of deaths from cancer of the breast was below expectation (10 observed, 22.3 expected) and no increased mortality from coronary disease was seen (102 observed, 100.9 expected). The mean dose of radiaton to the bone marrow has been determined for each woman and it is estimated that the excess rate of leukaemia in the first 20 years after treatment in about 1.1 per million women per year per rad. This figure is in accord with the estimates derived from the survivors of the atomic bomb explosions in Hiroshima and Nagasaki and among patients with ankylosing spondylitis treated with X-irradiation. However, the simple assumption of a linear dose response relationship for leukaemia is probably incorrect, at least when high doses of radiation are delivered to a small volume of marrow.}
journal = {Br. J. Radiol.; (United Kingdom)}
volume = {49:579}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Mar}
}