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Atomic bomb and leukemia

Journal Article:

Abstract

Characteristic features of the leukemia among atomic bomb survivors were studied. Dose estimates of atomic bomb radiation were based on T65D, but the new dosimetry system DS86 was used for some analyses. The ratio of a single leukemia type to all leukemias was highest for chronic myelogenous leukemia (CML) in Hiroshima, and the occurrence of CML was thought to be most characteristic to atomic bomb radiation induced leukemia. The threshold of CML occurrence in Hiroshima is likely to be between 0.5{approx}0.09 Gy. However, the threshold of acute leukemia appears to be nearly 1 Gy. In the distribution of acute myeloid leukemia (AML) subtypes by French-American-British classification, there was no M3 case in 1 Gy or more group, although several atypical AML cases of survivors were observed. Although aplastic anemia has not increased as a late effect of the atomic bomb radiation exposure, many atypical leukemia or other myeloproliferative diseases who had been diagnosed as aplastic anemia or its related diseases have been experienced among atomic bomb survivors. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral T-cells in several  More>>
Authors:
Ichimaru, M; Tomonaga, M; Amenomori, T; Matsuo, T [1] 
  1. Nagasaki Univ. (Japan). School of Medicine
Publication Date:
Dec 01, 1991
Product Type:
Journal Article
Reference Number:
JPN-92-008416; EDB-92-152784
Resource Relation:
Journal Name: Journal of Radiation Research; (Japan); Journal Volume: 32:suppl.2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; MYELOID LEUKEMIA; ANEMIAS; CHROMOSOMAL ABERRATIONS; CHROMOSOMES; DELAYED RADIATION EFFECTS; DOSIMETRY; THRESHOLD DOSE; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; DOSES; HEMIC DISEASES; HUMAN POPULATIONS; IMMUNE SYSTEM DISEASES; LEUKEMIA; MUTATIONS; NEOPLASMS; POPULATIONS; RADIATION DOSES; RADIATION EFFECTS; SYMPTOMS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7174286
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0449-3060; CODEN: JRARA
Submitting Site:
JPN
Size:
Pages: 14-19
Announcement Date:

Journal Article:

Citation Formats

Ichimaru, M, Tomonaga, M, Amenomori, T, and Matsuo, T. Atomic bomb and leukemia. Japan: N. p., 1991. Web.
Ichimaru, M, Tomonaga, M, Amenomori, T, & Matsuo, T. Atomic bomb and leukemia. Japan.
Ichimaru, M, Tomonaga, M, Amenomori, T, and Matsuo, T. 1991. "Atomic bomb and leukemia." Japan.
@misc{etde_7174286,
title = {Atomic bomb and leukemia}
author = {Ichimaru, M, Tomonaga, M, Amenomori, T, and Matsuo, T}
abstractNote = {Characteristic features of the leukemia among atomic bomb survivors were studied. Dose estimates of atomic bomb radiation were based on T65D, but the new dosimetry system DS86 was used for some analyses. The ratio of a single leukemia type to all leukemias was highest for chronic myelogenous leukemia (CML) in Hiroshima, and the occurrence of CML was thought to be most characteristic to atomic bomb radiation induced leukemia. The threshold of CML occurrence in Hiroshima is likely to be between 0.5{approx}0.09 Gy. However, the threshold of acute leukemia appears to be nearly 1 Gy. In the distribution of acute myeloid leukemia (AML) subtypes by French-American-British classification, there was no M3 case in 1 Gy or more group, although several atypical AML cases of survivors were observed. Although aplastic anemia has not increased as a late effect of the atomic bomb radiation exposure, many atypical leukemia or other myeloproliferative diseases who had been diagnosed as aplastic anemia or its related diseases have been experienced among atomic bomb survivors. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral T-cells in several atomic bomb survivors. (author).}
journal = {Journal of Radiation Research; (Japan)}
volume = {32:suppl.2}
journal type = {AC}
place = {Japan}
year = {1991}
month = {Dec}
}