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The synthesis of ( sup 3 H)-indole-3-carbinol, a natural anti-carcinogen from cruciferous vegetables

Abstract

Indole-3-carbinol is a natural anti-carcinogen found as a glucosinolate in cruciferous vegetables such as cabbage, cauliflower and broccoli. A complete understanding of the mechanisms of anti-carcinogenesis by this dietary inhibitor requires improved insight into the disposition and metabolic fate of indole-3-carbinol in vivo. Such metabolic studies have been hampered by the lack of a commercial source of radiolabelled compound. This provided the main impetus for the work reported here, the synthesis of 5-({sup 3}H)-indole-3-carbinol from 5-bromoindole. (author).
Authors:
Dashwood, R H; Uyetake, Lyle; Fong, A T; Hendricks, J D; Bailey, G S [1] 
  1. Oregon State Univ., Corvallis, OR (USA). Dept. of Food Science and Technology
Publication Date:
Aug 01, 1989
Product Type:
Journal Article
Reference Number:
AIX-21-030681; EDB-90-055085
Resource Relation:
Journal Name: Journal of Labelled Compounds and Radiopharmaceuticals; (UK); Journal Volume: 27:8
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ANTINEOPLASTIC DRUGS; RADIOPHARMACEUTICALS; INDOLES; BRASSICA; CHEMICAL PREPARATION; LABELLING; METHANOL; TRITIUM COMPOUNDS; ALCOHOLS; AROMATICS; AZAARENES; AZOLES; DRUGS; FOOD; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; LABELLED COMPOUNDS; MAGNOLIOPHYTA; MAGNOLIOPSIDA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; PYRROLES; SYNTHESIS; VEGETABLES; 400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
OSTI ID:
7170365
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0362-4803; CODEN: JLCRD; Other: CNN: NIEHS ESO3850; NIEHS ESO0210; NCI CA34732
Submitting Site:
GBN
Size:
Pages: 901-907
Announcement Date:

Citation Formats

Dashwood, R H, Uyetake, Lyle, Fong, A T, Hendricks, J D, and Bailey, G S. The synthesis of ( sup 3 H)-indole-3-carbinol, a natural anti-carcinogen from cruciferous vegetables. United Kingdom: N. p., 1989. Web. doi:10.1002/jlcr.2580270806.
Dashwood, R H, Uyetake, Lyle, Fong, A T, Hendricks, J D, & Bailey, G S. The synthesis of ( sup 3 H)-indole-3-carbinol, a natural anti-carcinogen from cruciferous vegetables. United Kingdom. doi:10.1002/jlcr.2580270806.
Dashwood, R H, Uyetake, Lyle, Fong, A T, Hendricks, J D, and Bailey, G S. 1989. "The synthesis of ( sup 3 H)-indole-3-carbinol, a natural anti-carcinogen from cruciferous vegetables." United Kingdom. doi:10.1002/jlcr.2580270806. https://www.osti.gov/servlets/purl/10.1002/jlcr.2580270806.
@misc{etde_7170365,
title = {The synthesis of ( sup 3 H)-indole-3-carbinol, a natural anti-carcinogen from cruciferous vegetables}
author = {Dashwood, R H, Uyetake, Lyle, Fong, A T, Hendricks, J D, and Bailey, G S}
abstractNote = {Indole-3-carbinol is a natural anti-carcinogen found as a glucosinolate in cruciferous vegetables such as cabbage, cauliflower and broccoli. A complete understanding of the mechanisms of anti-carcinogenesis by this dietary inhibitor requires improved insight into the disposition and metabolic fate of indole-3-carbinol in vivo. Such metabolic studies have been hampered by the lack of a commercial source of radiolabelled compound. This provided the main impetus for the work reported here, the synthesis of 5-({sup 3}H)-indole-3-carbinol from 5-bromoindole. (author).}
doi = {10.1002/jlcr.2580270806}
journal = {Journal of Labelled Compounds and Radiopharmaceuticals; (UK)}
volume = {27:8}
journal type = {AC}
place = {United Kingdom}
year = {1989}
month = {Aug}
}