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BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene

Abstract

A 0.7kb fragment generated by AvaII digestion of pBL13AI, a 0.965kb full-length human apolipoprotein AI cDNA was cloned into the EcoRI site of pBR322. The apoAI cDNA was isolated from a lambdagt10 human fetal liver cDNA library. BanII (GPuGCPyC) (International Biotechnologies, Inc.) identifies two invariant bands at 1122bp and 417bp, and a single two-allele polymorphism with bands at either 274bp or 452bp. The human apolipoprotein AI-CIII-AIV gene complex has been localized on the long arm of chromosome 11 by Southern blot analysis of human-chinese hamster cell hybrids. Co-dominant segregation has been observed in two families (13 individuals). The BanII restriction map was constructed from DNA sequence data of the human apoAI gene. The 452bp fragment is generated by the loss of a BanII dimorphic site in the third intron of the apoAI gene, between the 178bp and the 274bp fragments.
Publication Date:
Feb 11, 1988
Product Type:
Journal Article
Reference Number:
EDB-88-143796
Resource Relation:
Journal Name: Nucleic Acids Res.; (United Kingdom); Journal Volume: 16:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; APOLIPOPROTEINS; DNA SEQUENCING; GENETIC MAPPING; RECOMBINANT DNA; AUTORADIOGRAPHY; DNA-CLONING; GENES; CLONING; DNA; LIPIDS; LIPOPROTEINS; MAPPING; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; STRUCTURAL CHEMICAL ANALYSIS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550401 - Genetics- Tracer Techniques
OSTI ID:
7163665
Research Organizations:
California Biotechnology, Inc., Mountain View (USA)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 1221
Announcement Date:
Aug 01, 1988

Citation Formats

Coleman, R T, Kresnak, M T, and Frossard, P M. BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene. United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.3.1221.
Coleman, R T, Kresnak, M T, & Frossard, P M. BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene. United Kingdom. doi:10.1093/nar/16.3.1221.
Coleman, R T, Kresnak, M T, and Frossard, P M. 1988. "BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene." United Kingdom. doi:10.1093/nar/16.3.1221. https://www.osti.gov/servlets/purl/10.1093/nar/16.3.1221.
@misc{etde_7163665,
title = {BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene}
author = {Coleman, R T, Kresnak, M T, and Frossard, P M}
abstractNote = {A 0.7kb fragment generated by AvaII digestion of pBL13AI, a 0.965kb full-length human apolipoprotein AI cDNA was cloned into the EcoRI site of pBR322. The apoAI cDNA was isolated from a lambdagt10 human fetal liver cDNA library. BanII (GPuGCPyC) (International Biotechnologies, Inc.) identifies two invariant bands at 1122bp and 417bp, and a single two-allele polymorphism with bands at either 274bp or 452bp. The human apolipoprotein AI-CIII-AIV gene complex has been localized on the long arm of chromosome 11 by Southern blot analysis of human-chinese hamster cell hybrids. Co-dominant segregation has been observed in two families (13 individuals). The BanII restriction map was constructed from DNA sequence data of the human apoAI gene. The 452bp fragment is generated by the loss of a BanII dimorphic site in the third intron of the apoAI gene, between the 178bp and the 274bp fragments.}
doi = {10.1093/nar/16.3.1221}
journal = {Nucleic Acids Res.; (United Kingdom)}
volume = {16:3}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Feb}
}