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Radiation-induced myelopathy

Journal Article:

Abstract

12 cases of radiation-induced myelopathy after /sup 60/Co teletherapy are reported on. Among these were 10 thoracal lesions, one cerviothoracal lesion, and one lesion of the medulla oblongata. In 9 cases, Hodgkin's disease had been the primary disease, tow patients had been irradiated because of suspected vertebral metastases of cancer of the breast, and one patient had suffered from a glomus tumour of the petrous bone. The spinal doses had exceeded the tolerance doses recommended in the relevant literature. There was no close correlation between the radiation dose and the course of the disease. The latency periods between the end of the radiotherapy and the onset of the neurological symptons varied from 6 to 16 mouths and were very constant in 7 cases with 6 to 9 months. The segmental height of the lesion corresponded to the level of irradiation. The presenting symptons of radiation-induced myelopathy are buruing dysaesthesias and Brown-Sequard's paralysis which may develop into transverse lesion of the cord with paraplegia still accompanied by dissociated perception disorders. The disease developed intermittently. Disturbances of the bladder function are frequent. The fluid is normal in most cases. Myelographic examinations were made in 8 cases. 3 cases developed into stationary cases  More>>
Authors:
Gaenshirt, H [1] 
  1. Heidelberg Univ. (F.R. Germany). Neurologische Klinik
Publication Date:
Oct 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-255554; EDB-76-099046
Resource Relation:
Journal Name: Nervenarzt; (Germany, Federal Republic of); Journal Volume: 46:10; Other Information: 72 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NERVOUS SYSTEM DISEASES; RADIOINDUCTION; RADIOTHERAPY; SIDE EFFECTS; SPINAL CORD; BIOLOGICAL RADIATION EFFECTS; LATENCY PERIOD; PATHOGENESIS; RADIATION DOSES; RADIATION INJURIES; BIOLOGICAL EFFECTS; CENTRAL NERVOUS SYSTEM; DISEASES; DOSES; INJURIES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7147908
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: NERVA
Submitting Site:
INIS
Size:
Pages: 562-568
Announcement Date:
Sep 01, 1976

Journal Article:

Citation Formats

Gaenshirt, H. Radiation-induced myelopathy. Germany: N. p., 1975. Web.
Gaenshirt, H. Radiation-induced myelopathy. Germany.
Gaenshirt, H. 1975. "Radiation-induced myelopathy." Germany.
@misc{etde_7147908,
title = {Radiation-induced myelopathy}
author = {Gaenshirt, H}
abstractNote = {12 cases of radiation-induced myelopathy after /sup 60/Co teletherapy are reported on. Among these were 10 thoracal lesions, one cerviothoracal lesion, and one lesion of the medulla oblongata. In 9 cases, Hodgkin's disease had been the primary disease, tow patients had been irradiated because of suspected vertebral metastases of cancer of the breast, and one patient had suffered from a glomus tumour of the petrous bone. The spinal doses had exceeded the tolerance doses recommended in the relevant literature. There was no close correlation between the radiation dose and the course of the disease. The latency periods between the end of the radiotherapy and the onset of the neurological symptons varied from 6 to 16 mouths and were very constant in 7 cases with 6 to 9 months. The segmental height of the lesion corresponded to the level of irradiation. The presenting symptons of radiation-induced myelopathy are buruing dysaesthesias and Brown-Sequard's paralysis which may develop into transverse lesion of the cord with paraplegia still accompanied by dissociated perception disorders. The disease developed intermittently. Disturbances of the bladder function are frequent. The fluid is normal in most cases. Myelographic examinations were made in 8 cases. 3 cases developed into stationary cases exhibiting. Brown-Sequard syndrome, while 9 patients developed transverse lesion of the cord with paraplegia. 3 patients have died; antopsy findings are given for two of these. In the pathogenesis of radiation-induced myelopathy, the vascular factor is assumed to be of decisive importance.}
journal = {Nervenarzt; (Germany, Federal Republic of)}
volume = {46:10}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Oct}
}