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Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine

Journal Article:

Abstract

The sequence of histopathological changes was described after X-irradiation of the exteriorized segment (3 cm) of the rat ileum with a single dose of 2,200 R. A one-year follow-up was provided in rats whose exteriorized intestinal segments were irradiated. Comparisons were made between one group of animals in which the superior mesenteric artery and vein were clamped during irradiation and a second group in which these vessels were not clamped. A third group of sham-irradiated controls was used for comparisons. There was a delay in the onset and progression of the radiation damage to the mucosa of the hypoxic animals in the acute post-irradiation phase. In addition, prolongation of survival in the rats with the superior mesenteric vessels clamped was observed. Mucosal regeneration was noted, occurring at 52 days post-exposure. No adenocarcinomas were found up to 354 days after irradiation. An angiofibroma and a highly differentiated osteoid lesion were described.
Authors:
Sebes, J I; Zaldivar, R; Vogel, Jr, H H; [1]  Tennessee Univ., Memphis (USA). Dept. of Diagnostic Radiology)
  1. Tennessee Univ., Memphis (USA). Dept. of Radiation Oncology
Publication Date:
Oct 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-255533; EDB-76-099104
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 150:4; Other Information: 5 figs.; 1 tab.; 20 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SMALL INTESTINE; BIOLOGICAL RADIATION EFFECTS; ANGIOMAS; BIOLOGICAL RECOVERY; CARCINOMAS; HISTOLOGY; MUCOUS MEMBRANES; PATHOLOGY; RADIATION DOSE UNITS; RADIOBIOLOGY; RATS; SURVIVAL TIME; TIME DEPENDENCE; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGY; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; GASTROINTESTINAL TRACT; INTESTINES; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; ORGANS; RADIATION EFFECTS; RADIATIONS; RECOVERY; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7147880
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 403-410
Announcement Date:
Sep 01, 1976

Journal Article:

Citation Formats

Sebes, J I, Zaldivar, R, Vogel, Jr, H H, and Tennessee Univ., Memphis (USA). Dept. of Diagnostic Radiology). Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine. Germany: N. p., 1975. Web.
Sebes, J I, Zaldivar, R, Vogel, Jr, H H, & Tennessee Univ., Memphis (USA). Dept. of Diagnostic Radiology). Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine. Germany.
Sebes, J I, Zaldivar, R, Vogel, Jr, H H, and Tennessee Univ., Memphis (USA). Dept. of Diagnostic Radiology). 1975. "Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine." Germany.
@misc{etde_7147880,
title = {Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine}
author = {Sebes, J I, Zaldivar, R, Vogel, Jr, H H, and Tennessee Univ., Memphis (USA). Dept. of Diagnostic Radiology)}
abstractNote = {The sequence of histopathological changes was described after X-irradiation of the exteriorized segment (3 cm) of the rat ileum with a single dose of 2,200 R. A one-year follow-up was provided in rats whose exteriorized intestinal segments were irradiated. Comparisons were made between one group of animals in which the superior mesenteric artery and vein were clamped during irradiation and a second group in which these vessels were not clamped. A third group of sham-irradiated controls was used for comparisons. There was a delay in the onset and progression of the radiation damage to the mucosa of the hypoxic animals in the acute post-irradiation phase. In addition, prolongation of survival in the rats with the superior mesenteric vessels clamped was observed. Mucosal regeneration was noted, occurring at 52 days post-exposure. No adenocarcinomas were found up to 354 days after irradiation. An angiofibroma and a highly differentiated osteoid lesion were described.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {150:4}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Oct}
}