Abstract
The effect of dose fractionation on the induction of translocations by 400 and 600 rad X-rays in spermatogonia of guinea-pigs and hamsters was investigated cytologically. Three types of fractionation were used, dividing the dose into (a) two equal fractions 24h apart, (b) two equal fractions 8 weeks apart, and (c) eight or twelve equal fractions of 50 rad, at intervals of one week. The two species responded similarly throughout, but gave lower translocation yields than the mouse. The effects of the first and third types of fractionation were similar to those described previously in the mouse, and suggested that a first radiation dose modifies the spermatogonial population so that its sensitivity to a dose 24h later is altered, and that repeated radiation doses result in development of resistance to translocation induction. After 8-week fractionation, the results suggested that in guinea-pigs and hamsters, the spermatogonial population had not returned to normal by 8 weeks after the first dose, whereas in the mouse, normal sensitivity had returned by this time. The results, reported previously, of single doses of X-rays suggest that the spermatogonial population consists of sub-populations differing in sensitivity to cell killing and genetic effects. The effects of fractionated doses in
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Citation Formats
Lyon, M F, and Cox, B D.
Induction by X-rays of chromosome aberrations in male guinea-pigs and golden hamsters. 4. Dose-response for spermatogonia treated with fractionated doses.
Netherlands: N. p.,
1975.
Web.
Lyon, M F, & Cox, B D.
Induction by X-rays of chromosome aberrations in male guinea-pigs and golden hamsters. 4. Dose-response for spermatogonia treated with fractionated doses.
Netherlands.
Lyon, M F, and Cox, B D.
1975.
"Induction by X-rays of chromosome aberrations in male guinea-pigs and golden hamsters. 4. Dose-response for spermatogonia treated with fractionated doses."
Netherlands.
@misc{etde_7144976,
title = {Induction by X-rays of chromosome aberrations in male guinea-pigs and golden hamsters. 4. Dose-response for spermatogonia treated with fractionated doses}
author = {Lyon, M F, and Cox, B D}
abstractNote = {The effect of dose fractionation on the induction of translocations by 400 and 600 rad X-rays in spermatogonia of guinea-pigs and hamsters was investigated cytologically. Three types of fractionation were used, dividing the dose into (a) two equal fractions 24h apart, (b) two equal fractions 8 weeks apart, and (c) eight or twelve equal fractions of 50 rad, at intervals of one week. The two species responded similarly throughout, but gave lower translocation yields than the mouse. The effects of the first and third types of fractionation were similar to those described previously in the mouse, and suggested that a first radiation dose modifies the spermatogonial population so that its sensitivity to a dose 24h later is altered, and that repeated radiation doses result in development of resistance to translocation induction. After 8-week fractionation, the results suggested that in guinea-pigs and hamsters, the spermatogonial population had not returned to normal by 8 weeks after the first dose, whereas in the mouse, normal sensitivity had returned by this time. The results, reported previously, of single doses of X-rays suggest that the spermatogonial population consists of sub-populations differing in sensitivity to cell killing and genetic effects. The effects of fractionated doses in the mouse suggest that the sensitive and resistant types represent different phases of the samecell type rather than two distinct types of cell. In the guinea-pig and hamster, this question remains open.}
journal = []
volume = {30:1}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Oct}
}
title = {Induction by X-rays of chromosome aberrations in male guinea-pigs and golden hamsters. 4. Dose-response for spermatogonia treated with fractionated doses}
author = {Lyon, M F, and Cox, B D}
abstractNote = {The effect of dose fractionation on the induction of translocations by 400 and 600 rad X-rays in spermatogonia of guinea-pigs and hamsters was investigated cytologically. Three types of fractionation were used, dividing the dose into (a) two equal fractions 24h apart, (b) two equal fractions 8 weeks apart, and (c) eight or twelve equal fractions of 50 rad, at intervals of one week. The two species responded similarly throughout, but gave lower translocation yields than the mouse. The effects of the first and third types of fractionation were similar to those described previously in the mouse, and suggested that a first radiation dose modifies the spermatogonial population so that its sensitivity to a dose 24h later is altered, and that repeated radiation doses result in development of resistance to translocation induction. After 8-week fractionation, the results suggested that in guinea-pigs and hamsters, the spermatogonial population had not returned to normal by 8 weeks after the first dose, whereas in the mouse, normal sensitivity had returned by this time. The results, reported previously, of single doses of X-rays suggest that the spermatogonial population consists of sub-populations differing in sensitivity to cell killing and genetic effects. The effects of fractionated doses in the mouse suggest that the sensitive and resistant types represent different phases of the samecell type rather than two distinct types of cell. In the guinea-pig and hamster, this question remains open.}
journal = []
volume = {30:1}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Oct}
}