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Activity of certain enzymes of the gastrointestinal tract and of their inhibitors under the action of radiation and thiophosphamide

Abstract

Total-body X-irradiation (600 r) of rats and administration of thiophosphamide (13 mg/kg) increased the activity of trypsin of pancreas and serum of rats, six hours after treatment. An increased activity is maintained over a long period of time after the exposure (up to 60 days), whereas after treatment with thiophosphamide, it starts decreasing below normal on the 7th day. The pepsin activity in the gastric wall decreases early after the irradiation, then it rises (days 3 to 7) and falls again. The administration of thiophosphamide does not substantially influence the activity of pepsin. One of the factors responsible for the variations observed in the activity of enzymes may be the changes in the contents of serum inhibitors of trypsin and pepsin.
Authors:
Savitskii, I V; Korpovich, G A [1] 
  1. Odesskij Meditsinskij Inst. (Ukrainian SSR)
Publication Date:
Jan 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-315276; EDB-77-121921
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 15:1; Other Information: For English translation see the journal Radiobiology
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ORGANIC PHOSPHORUS COMPOUNDS; BIOLOGICAL EFFECTS; X RADIATION; BIOLOGICAL RADIATION EFFECTS; AMIDES; ANIMALS; BLOOD SERUM; GASTROINTESTINAL TRACT; INHIBITION; IRRADIATION; PANCREAS; PEPSIN; RADIOMIMETIC DRUGS; RESPONSE MODIFYING FACTORS; TRYPSIN; BODY; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; ENZYMES; GLANDS; HYDROLASES; IONIZING RADIATIONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; RADIATION EFFECTS; RADIATIONS; 560114* - Radiation Effects on Biochemicals- In Animals- (-1987); 560121 - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7142853
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 120-124
Announcement Date:
Aug 01, 1977

Citation Formats

Savitskii, I V, and Korpovich, G A. Activity of certain enzymes of the gastrointestinal tract and of their inhibitors under the action of radiation and thiophosphamide. USSR: N. p., 1975. Web.
Savitskii, I V, & Korpovich, G A. Activity of certain enzymes of the gastrointestinal tract and of their inhibitors under the action of radiation and thiophosphamide. USSR.
Savitskii, I V, and Korpovich, G A. 1975. "Activity of certain enzymes of the gastrointestinal tract and of their inhibitors under the action of radiation and thiophosphamide." USSR.
@misc{etde_7142853,
title = {Activity of certain enzymes of the gastrointestinal tract and of their inhibitors under the action of radiation and thiophosphamide}
author = {Savitskii, I V, and Korpovich, G A}
abstractNote = {Total-body X-irradiation (600 r) of rats and administration of thiophosphamide (13 mg/kg) increased the activity of trypsin of pancreas and serum of rats, six hours after treatment. An increased activity is maintained over a long period of time after the exposure (up to 60 days), whereas after treatment with thiophosphamide, it starts decreasing below normal on the 7th day. The pepsin activity in the gastric wall decreases early after the irradiation, then it rises (days 3 to 7) and falls again. The administration of thiophosphamide does not substantially influence the activity of pepsin. One of the factors responsible for the variations observed in the activity of enzymes may be the changes in the contents of serum inhibitors of trypsin and pepsin.}
journal = []
volume = {15:1}
journal type = {AC}
place = {USSR}
year = {1975}
month = {Jan}
}