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Evaluation and re-evaluation of genetic radiation hazards in man. The arm number hypothesis and the induction of reciprocal translocations in man. II

Journal Article:

Abstract

The arm number hypothesis proposed by Brewen and colleagues in 1973 has been examined in the light of information thus far available from mammalian studies. In experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, Chinese hamster, goat, sheep, pig, wallaby and man. However, the data are not consistent with such a relationship in several primate species (marmoset, rhesus monkey, cynomolgus monkey, squirrel monkey and the slow loris), the cat and the dog. In the rabbit, the data are conflicting. In the mouse and the Chinese hamster the frequencies of reciprocal translocations recorded in spermatocytes descended from irradiated spermatogonia are in line with the expectation based on the arm number hypothesis, whereas in the golden hamster, rabbit and the rhesus they are not. In man and the marmoset, the limited data are not inconsistent with a 2-fold higher sensitivity of these species relative to the mouse although they do not rule out a difference as high as 4-fold. In the guinea-pig, the situation is unclear. New data on the transmission of reciprocal translocations in mice suggest that the frequency in the  More>>
Authors:
Sankaranarayanan, K; [1]  Cohen (J.A.) Instituut voor Radiopathologie en Stralenbescherming, Leiden (Netherlands))
  1. Rijksuniversiteit Leiden (Netherlands). Lab. voor Stralengenetica en Chemische Mutagenese
Publication Date:
Jun 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-07-268423; EDB-77-008960
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 35:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; ANIMAL CELLS; COMPARATIVE EVALUATIONS; DICENTRIC CHROMOSOMES; EXTRAPOLATION; GENETIC RADIATION EFFECTS; MAN; MICE; MONKEYS; MUTATION FREQUENCY; RABBITS; SPERMATOCYTES; TRANSLOCATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CHROMOSOMES; GENETIC EFFECTS; GERM CELLS; MAMMALS; MUTATIONS; NUMERICAL SOLUTION; PRIMATES; RADIATION EFFECTS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560151 - Radiation Effects on Animals- Man
OSTI ID:
7141456
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 371-386
Announcement Date:

Journal Article:

Citation Formats

Sankaranarayanan, K, and Cohen (J.A.) Instituut voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)). Evaluation and re-evaluation of genetic radiation hazards in man. The arm number hypothesis and the induction of reciprocal translocations in man. II. Netherlands: N. p., 1976. Web.
Sankaranarayanan, K, & Cohen (J.A.) Instituut voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)). Evaluation and re-evaluation of genetic radiation hazards in man. The arm number hypothesis and the induction of reciprocal translocations in man. II. Netherlands.
Sankaranarayanan, K, and Cohen (J.A.) Instituut voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)). 1976. "Evaluation and re-evaluation of genetic radiation hazards in man. The arm number hypothesis and the induction of reciprocal translocations in man. II." Netherlands.
@misc{etde_7141456,
title = {Evaluation and re-evaluation of genetic radiation hazards in man. The arm number hypothesis and the induction of reciprocal translocations in man. II}
author = {Sankaranarayanan, K, and Cohen (J.A.) Instituut voor Radiopathologie en Stralenbescherming, Leiden (Netherlands))}
abstractNote = {The arm number hypothesis proposed by Brewen and colleagues in 1973 has been examined in the light of information thus far available from mammalian studies. In experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, Chinese hamster, goat, sheep, pig, wallaby and man. However, the data are not consistent with such a relationship in several primate species (marmoset, rhesus monkey, cynomolgus monkey, squirrel monkey and the slow loris), the cat and the dog. In the rabbit, the data are conflicting. In the mouse and the Chinese hamster the frequencies of reciprocal translocations recorded in spermatocytes descended from irradiated spermatogonia are in line with the expectation based on the arm number hypothesis, whereas in the golden hamster, rabbit and the rhesus they are not. In man and the marmoset, the limited data are not inconsistent with a 2-fold higher sensitivity of these species relative to the mouse although they do not rule out a difference as high as 4-fold. In the guinea-pig, the situation is unclear. New data on the transmission of reciprocal translocations in mice suggest that the frequency in the F/sub 1/ progeny may be close to one-quarter of that recorded in the spermatocytes of the irradiated fathers (spermatogonial irradiation) at an exposure level of 150 R, whereas at higher exposures, the reduction factor is about one-eighth, the latter being in line with the earlier finding. All these results taken together suggest that inter-specific extrapolation from the radiosensitivity of somatic cells (to dicentric induction) to that of germ cells (to translocation induction) is fraught with uncertainty at present. Certain aspects that need to be studied in more detail in the context of induced chromosome aberrations are discussed.}
journal = {Mutat. Res.; (Netherlands)}
volume = {35:3}
journal type = {AC}
place = {Netherlands}
year = {1976}
month = {Jun}
}