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Radiation chemistry of DNA. II. Strand breaks and sugar release by. gamma. -irradiation of DNA in aqueous solution. The effect of oxygen

Journal Article:

Abstract

From ..gamma..-irradiated oxygenated aqueous solutions of DNA, 2-deoxy-tetrodialdose (1) and 2-deoxy-pentos-4-ulose (2) have been isolated as free sugars. The formation of 1 indicates that in the presence of oxygen the DNA strand is not only broken by mere phosphate ester cleavage but also by C-C-bond rupture in the sugar moiety. Such a process has not been encountered in deoxygenated solutions so far. The mechanism for the formation of 1 is discussed.
Authors:
Dizdaroglu, M; Schulte-Frohlinde, D; von Sonntag, C [1] 
  1. Max-Planck-Institut fuer Kohlenforschung, Muelheim an der Ruhr (F.R. Germany). Abt. fuer Strahlenchemie
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-262635; EDB-77-020398
Resource Relation:
Journal Name: Z. Naturforsch., c; (Germany, Federal Republic of); Journal Volume: 30:6; Other Information: 10 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; RADIATION CHEMISTRY; STRAND BREAKS; RADIOINDUCTION; AQUEOUS SOLUTIONS; GAMMA RADIATION; IRRADIATION; OXYGEN; PHOTON BEAMS; RADIATION EFFECTS; RADICALS; SACCHAROSE; BEAMS; CARBOHYDRATES; CHEMISTRY; CRYOGENIC FLUIDS; DISACCHARIDES; DISPERSIONS; ELECTROMAGNETIC RADIATION; ELEMENTS; FLUIDS; IONIZING RADIATIONS; MIXTURES; NONMETALS; NUCLEIC ACIDS; OLIGOSACCHARIDES; ORGANIC COMPOUNDS; RADIATIONS; SACCHARIDES; SOLUTIONS; 560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
OSTI ID:
7137390
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ZNFCA
Submitting Site:
INIS
Size:
Pages: 826-828
Announcement Date:
Oct 01, 1976

Journal Article:

Citation Formats

Dizdaroglu, M, Schulte-Frohlinde, D, and von Sonntag, C. Radiation chemistry of DNA. II. Strand breaks and sugar release by. gamma. -irradiation of DNA in aqueous solution. The effect of oxygen. Germany: N. p., 1975. Web.
Dizdaroglu, M, Schulte-Frohlinde, D, & von Sonntag, C. Radiation chemistry of DNA. II. Strand breaks and sugar release by. gamma. -irradiation of DNA in aqueous solution. The effect of oxygen. Germany.
Dizdaroglu, M, Schulte-Frohlinde, D, and von Sonntag, C. 1975. "Radiation chemistry of DNA. II. Strand breaks and sugar release by. gamma. -irradiation of DNA in aqueous solution. The effect of oxygen." Germany.
@misc{etde_7137390,
title = {Radiation chemistry of DNA. II. Strand breaks and sugar release by. gamma. -irradiation of DNA in aqueous solution. The effect of oxygen}
author = {Dizdaroglu, M, Schulte-Frohlinde, D, and von Sonntag, C}
abstractNote = {From ..gamma..-irradiated oxygenated aqueous solutions of DNA, 2-deoxy-tetrodialdose (1) and 2-deoxy-pentos-4-ulose (2) have been isolated as free sugars. The formation of 1 indicates that in the presence of oxygen the DNA strand is not only broken by mere phosphate ester cleavage but also by C-C-bond rupture in the sugar moiety. Such a process has not been encountered in deoxygenated solutions so far. The mechanism for the formation of 1 is discussed.}
journal = {Z. Naturforsch., c; (Germany, Federal Republic of)}
volume = {30:6}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Nov}
}