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Bone marrow transplantation in severe aplastic anemia and acute or chronic leukemia

Conference:

Abstract

In Essen 121 bone marrow transplantations were carried out. The indications were severe aplastic anemia, acute leukemia in relapse, acute leukemia in remission or chronic myeloid leukemia. The conditioning regimen consisted of cyclophosphamide or the combination of cyclophosphamide and total body irradiation. All patients were treated under strict gnotobiotic care. To mitigate the risk of CMV infections intravenous CMV-hyperimmunoglobulin and CMV-negative blood products have been applied routinely since two years. MTX was used as prophylaxis against GVH-disease. In case of severe aplastic anemia 13 patients (72%) are still alive with a median observation time of 24 months. In the prognostically unfavourable group of acute leukemia in relapse only one patient showed long term survival. In this patient leukemic relapse occurred six years after transplantation. The survival rate of AML patients grafted during the first remission is 55% with a median observation time of 40 months. For patients grafted in the first consecutive remission of ALL the survival rate is 42% with a maximal observation time of 29 months. Out of 37 patients grafted because of CML, eight were in an advanced stage of the disease. 13 patients are still alive, the maximal observation time is 37 months. The overall incidence  More>>
Publication Date:
Apr 01, 1986
Product Type:
Conference
Report Number:
CONF-8509354-
Reference Number:
DEN-87-000342; EDB-87-034089
Resource Relation:
Journal Name: Strahlenther. Onkol.; (Germany, Federal Republic of); Journal Volume: 162:4; Conference: Seminar and workshop on physical problems of total body irradiation, Essen, F.R. Germany, 19 Sep 1985
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEUKEMIA; RADIOTHERAPY; POST-IRRADIATION THERAPY; TRANSPLANTS; BONE MARROW CELLS; CHEMOTHERAPY; EFFICIENCY; ENDOXAN; PATIENTS; PREVENTIVE MEDICINE; SURVIVAL CURVES; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMAL CELLS; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMIC DISEASES; IMMUNOSUPPRESSIVE DRUGS; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; SOMATIC CELLS; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man
OSTI ID:
7133702
Research Organizations:
Essen Univ., Gesamthochschule, Germany, F.R. Innere Klinik und Poliklinik - Tumorforschung; Essen Univ., Gesamthochschule, Germany, F.R. Strahlenklinik; Essen Univ., Gesamthochschule, Germany, F.R. Abt. fuer Medizinische Mikrobiologie
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STONE
Submitting Site:
DEN
Size:
Pages: 214-217
Announcement Date:

Conference:

Citation Formats

Schaefer, U W, Mahmoud, H K, Beelen, D W, Hoffmann, W, Becher, R, Schmidt, C G, Bamberg, M, Quast, U, Haralambie, E, and Linzenmeier, G. Bone marrow transplantation in severe aplastic anemia and acute or chronic leukemia. Germany: N. p., 1986. Web.
Schaefer, U W, Mahmoud, H K, Beelen, D W, Hoffmann, W, Becher, R, Schmidt, C G, Bamberg, M, Quast, U, Haralambie, E, & Linzenmeier, G. Bone marrow transplantation in severe aplastic anemia and acute or chronic leukemia. Germany.
Schaefer, U W, Mahmoud, H K, Beelen, D W, Hoffmann, W, Becher, R, Schmidt, C G, Bamberg, M, Quast, U, Haralambie, E, and Linzenmeier, G. 1986. "Bone marrow transplantation in severe aplastic anemia and acute or chronic leukemia." Germany.
@misc{etde_7133702,
title = {Bone marrow transplantation in severe aplastic anemia and acute or chronic leukemia}
author = {Schaefer, U W, Mahmoud, H K, Beelen, D W, Hoffmann, W, Becher, R, Schmidt, C G, Bamberg, M, Quast, U, Haralambie, E, and Linzenmeier, G}
abstractNote = {In Essen 121 bone marrow transplantations were carried out. The indications were severe aplastic anemia, acute leukemia in relapse, acute leukemia in remission or chronic myeloid leukemia. The conditioning regimen consisted of cyclophosphamide or the combination of cyclophosphamide and total body irradiation. All patients were treated under strict gnotobiotic care. To mitigate the risk of CMV infections intravenous CMV-hyperimmunoglobulin and CMV-negative blood products have been applied routinely since two years. MTX was used as prophylaxis against GVH-disease. In case of severe aplastic anemia 13 patients (72%) are still alive with a median observation time of 24 months. In the prognostically unfavourable group of acute leukemia in relapse only one patient showed long term survival. In this patient leukemic relapse occurred six years after transplantation. The survival rate of AML patients grafted during the first remission is 55% with a median observation time of 40 months. For patients grafted in the first consecutive remission of ALL the survival rate is 42% with a maximal observation time of 29 months. Out of 37 patients grafted because of CML, eight were in an advanced stage of the disease. 13 patients are still alive, the maximal observation time is 37 months. The overall incidence of GVHD in patients at risk was 28% in aplastic anemia, 26% in AML, 9% in ALL and 63% in CML. In aplastic anemia no patient developed an interstitial pneumonia. In leukemia the risk of fatal interstitial pneumonia was 34%.}
journal = {Strahlenther. Onkol.; (Germany, Federal Republic of)}
volume = {162:4}
place = {Germany}
year = {1986}
month = {Apr}
}