Abstract
Rats were injected with (/sup 125/I)L-thyroxine (T/sub 4/) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin-injected animals. In each sample of plasma T/sub 4/ counts per ml were estimated with the acid of paper chromatography. Rapid decrease of circulating T/sub 4/ level was found at 20 min after iv injection of thiocyanate, iodide, fluoroborate, theophylline and salicylate and a dose-response relationship was established between such a decrease and the administered dose of salicylate (5-160 mg/400 g b.w.). A similar decrease was observed at 60 min after ip injection of some general anaesthetics or tranquilizers. An increase of T/sub 4/ fractional disposal rate was found between 120 and 480 min after the administration of some of the anaesthetics and this effect was abolished by the administration of thiocyanate. It was concluded that there are two different effects of drugs on the circulating T/sub 4/ level: 1. the immediate effect resulting apparently from a decreased plasma protein binding. 2. the prolonged effect which presumably results from the increased turnover of T/sub 4/ by peripheral tissues, the metabolic basis of which remains unexplained.
Langer, P;
Kokesova, H;
Gschwendtova, K
[1]
- Slovenska Akademia Vied, Bratislava (Czechoslovakia). Ustav Experimentalni Endocrinologie
Citation Formats
Langer, P, Kokesova, H, and Gschwendtova, K.
Acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats.
Denmark: N. p.,
1976.
Web.
Langer, P, Kokesova, H, & Gschwendtova, K.
Acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats.
Denmark.
Langer, P, Kokesova, H, and Gschwendtova, K.
1976.
"Acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats."
Denmark.
@misc{etde_7133175,
title = {Acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats}
author = {Langer, P, Kokesova, H, and Gschwendtova, K}
abstractNote = {Rats were injected with (/sup 125/I)L-thyroxine (T/sub 4/) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin-injected animals. In each sample of plasma T/sub 4/ counts per ml were estimated with the acid of paper chromatography. Rapid decrease of circulating T/sub 4/ level was found at 20 min after iv injection of thiocyanate, iodide, fluoroborate, theophylline and salicylate and a dose-response relationship was established between such a decrease and the administered dose of salicylate (5-160 mg/400 g b.w.). A similar decrease was observed at 60 min after ip injection of some general anaesthetics or tranquilizers. An increase of T/sub 4/ fractional disposal rate was found between 120 and 480 min after the administration of some of the anaesthetics and this effect was abolished by the administration of thiocyanate. It was concluded that there are two different effects of drugs on the circulating T/sub 4/ level: 1. the immediate effect resulting apparently from a decreased plasma protein binding. 2. the prolonged effect which presumably results from the increased turnover of T/sub 4/ by peripheral tissues, the metabolic basis of which remains unexplained.}
journal = []
volume = {81}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}
title = {Acute redistribution of thyroxine after the administration of univalent anions, salicylate, theophylline and barbiturates in rats}
author = {Langer, P, Kokesova, H, and Gschwendtova, K}
abstractNote = {Rats were injected with (/sup 125/I)L-thyroxine (T/sub 4/) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin-injected animals. In each sample of plasma T/sub 4/ counts per ml were estimated with the acid of paper chromatography. Rapid decrease of circulating T/sub 4/ level was found at 20 min after iv injection of thiocyanate, iodide, fluoroborate, theophylline and salicylate and a dose-response relationship was established between such a decrease and the administered dose of salicylate (5-160 mg/400 g b.w.). A similar decrease was observed at 60 min after ip injection of some general anaesthetics or tranquilizers. An increase of T/sub 4/ fractional disposal rate was found between 120 and 480 min after the administration of some of the anaesthetics and this effect was abolished by the administration of thiocyanate. It was concluded that there are two different effects of drugs on the circulating T/sub 4/ level: 1. the immediate effect resulting apparently from a decreased plasma protein binding. 2. the prolonged effect which presumably results from the increased turnover of T/sub 4/ by peripheral tissues, the metabolic basis of which remains unexplained.}
journal = []
volume = {81}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}