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Biosynthesis of Corynecins by Corynebacterium hydrocarboclastus. On the origin of the N-acyl group

Journal Article:

Abstract

1) The addition of amino acids, such as threonine, homoserine and methionine, to producing cultures resulted in an increase of the production of Corynecin 2. ..cap alpha..-Ketobutyric acid showed the similar effect. 2) The incorporation of these amino acids and the ketoacid into the propionyl group of Corynecin 2 was confirmed by the feeding experiments with labeled compounds, whereas propionic acid-U/sup 14/C was incorporated poorly into Corynecins with a relatively high degree of randomization of radioactivities. 3) L-Valine-U/sup 14/C was incorporated into Corynecin 3, suggesting that the isobutyryl group of Corynecin 3 was derived from L-valine via ..cap alpha..-ketoisovalerate. 4) The origin of the acetyl group of Corynecin I was discussed on the basis of the incorporation experiments with acetate, pyruvate and L-alanine, all labeled with /sup 14/C.
Authors:
Nakano, H; Tomita, F; Suzuki, T [1] 
  1. Kyowa Hakko Kogyo Co. Ltd., Tokyo (Japan)
Publication Date:
Feb 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-290118; EDB-77-045213
Resource Relation:
Journal Name: Agric. Biol. Chem. (Tokyo); (Japan); Journal Volume: 40:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; AMINO ACIDS; UPTAKE; PROTEINS; BIOSYNTHESIS; CARBON 14 COMPOUNDS; LABELLED COMPOUNDS; MICROCOCCUS; TRACER TECHNIQUES; BACTERIA; CARBOXYLIC ACIDS; ISOTOPE APPLICATIONS; MICROORGANISMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS; 550701* - Microbiology- Tracer Techniques
OSTI ID:
7128004
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ABCHA
Submitting Site:
INIS
Size:
Pages: 331-336
Announcement Date:

Journal Article:

Citation Formats

Nakano, H, Tomita, F, and Suzuki, T. Biosynthesis of Corynecins by Corynebacterium hydrocarboclastus. On the origin of the N-acyl group. Japan: N. p., 1976. Web.
Nakano, H, Tomita, F, & Suzuki, T. Biosynthesis of Corynecins by Corynebacterium hydrocarboclastus. On the origin of the N-acyl group. Japan.
Nakano, H, Tomita, F, and Suzuki, T. 1976. "Biosynthesis of Corynecins by Corynebacterium hydrocarboclastus. On the origin of the N-acyl group." Japan.
@misc{etde_7128004,
title = {Biosynthesis of Corynecins by Corynebacterium hydrocarboclastus. On the origin of the N-acyl group}
author = {Nakano, H, Tomita, F, and Suzuki, T}
abstractNote = {1) The addition of amino acids, such as threonine, homoserine and methionine, to producing cultures resulted in an increase of the production of Corynecin 2. ..cap alpha..-Ketobutyric acid showed the similar effect. 2) The incorporation of these amino acids and the ketoacid into the propionyl group of Corynecin 2 was confirmed by the feeding experiments with labeled compounds, whereas propionic acid-U/sup 14/C was incorporated poorly into Corynecins with a relatively high degree of randomization of radioactivities. 3) L-Valine-U/sup 14/C was incorporated into Corynecin 3, suggesting that the isobutyryl group of Corynecin 3 was derived from L-valine via ..cap alpha..-ketoisovalerate. 4) The origin of the acetyl group of Corynecin I was discussed on the basis of the incorporation experiments with acetate, pyruvate and L-alanine, all labeled with /sup 14/C.}
journal = {Agric. Biol. Chem. (Tokyo); (Japan)}
volume = {40:2}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Feb}
}