You need JavaScript to view this

Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia

Thesis/Dissertation:

Abstract

The overall aim of this study was a comprehensive assessment of the nature and severity of the late effects of treatment in a group of children surviving acute lymphoblastic leukaemia. In the absence of damage preceding treatment, late effects could be ascribed to treatment. Cranial irradiation, methotrexate, L-asparaginase and cytosine arabinoside are therapeutic modalities most likely to cause injury to the central nervous system. Survivors of childhood leukaemia also showed an increase in weight-for-height during and after therapy which appeared to be the consequence of a loss in statural growth as well as increasing weight-for-age. Assessment of endocrine function in leukaemia survivors indicated abnormalities in the regulation of growth hormone and thyroid stimulating hormone in some patients. Survivors of childhood leukaemia were shown to have an intellectual deficit compared with their siblings and a high incidence of visual-perceptual defects. The intellectual effects of lower doses of cranial irradiation are as yet unknown. A variety of minor neurological abnormalities were detected among leukaemia survivors and thought to be related to preceding central nervous system 'prophylactic' chemotherapy and irradiation. A new instrument, the functional deficit score, was derived to reflect overall outcome in survivors of childhood leukaemia. With few exceptions, leukaemia survivors  More>>
Authors:
Publication Date:
Jan 01, 1987
Product Type:
Thesis/Dissertation
Reference Number:
AIX-19-083792; EDB-88-157801
Resource Relation:
Other Information: Thesis (Ph.D)
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; CENTRAL NERVOUS SYSTEM; DELAYED RADIATION EFFECTS; LEUKEMIA; RADIOTHERAPY; ANIMAL GROWTH; CHEMOTHERAPY; CHILDREN; COMBINED THERAPY; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; DRUGS; ENDOCRINE GLANDS; EXPERIMENTAL DATA; HEART; HEIGHT; HORMONES; IRRADIATION; LIVER; LUNGS; LYMPHATIC SYSTEM; NEUROLOGY; PATHOLOGY; PATIENTS; RADIATION DOSES; SURVIVAL CURVES; TOXICITY; WEIGHT; X RADIATION; AGE GROUPS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; DATA; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DIMENSIONS; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; GLANDS; GROWTH; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; INFORMATION; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; TOMOGRAPHY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
7125553
Research Organizations:
Cape Town Univ. (South Africa)
Country of Origin:
South Africa
Language:
English
Availability:
Registrar, University of Cape Town, University Private Bag, Rondebosch, 7700, South Africa.
Submitting Site:
INIS
Size:
Pages: 424
Announcement Date:

Thesis/Dissertation:

Citation Formats

Roux, P. Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia. South Africa: N. p., 1987. Web.
Roux, P. Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia. South Africa.
Roux, P. 1987. "Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia." South Africa.
@misc{etde_7125553,
title = {Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia}
author = {Roux, P}
abstractNote = {The overall aim of this study was a comprehensive assessment of the nature and severity of the late effects of treatment in a group of children surviving acute lymphoblastic leukaemia. In the absence of damage preceding treatment, late effects could be ascribed to treatment. Cranial irradiation, methotrexate, L-asparaginase and cytosine arabinoside are therapeutic modalities most likely to cause injury to the central nervous system. Survivors of childhood leukaemia also showed an increase in weight-for-height during and after therapy which appeared to be the consequence of a loss in statural growth as well as increasing weight-for-age. Assessment of endocrine function in leukaemia survivors indicated abnormalities in the regulation of growth hormone and thyroid stimulating hormone in some patients. Survivors of childhood leukaemia were shown to have an intellectual deficit compared with their siblings and a high incidence of visual-perceptual defects. The intellectual effects of lower doses of cranial irradiation are as yet unknown. A variety of minor neurological abnormalities were detected among leukaemia survivors and thought to be related to preceding central nervous system 'prophylactic' chemotherapy and irradiation. A new instrument, the functional deficit score, was derived to reflect overall outcome in survivors of childhood leukaemia. With few exceptions, leukaemia survivors in this study had received 2400 rads of deep x-ray therapy as cranial irradiation. This dosage has since been reduced world-wide. Current cranial irradiation 'prophylaxis' consists of 1800 rad of megavoltage radiotherapy.}
place = {South Africa}
year = {1987}
month = {Jan}
}