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Effects of amalgam corrosion products on human cells

Abstract

Using three independent criteria, we have found that 10/sup -4/,10/sup -6/M concentrations of ions presumably liberated from the corrosion of dental amalgam produce injurious effects on either human gingival fibroblasts or HeLa cells when the cells are grown in culture. Release of /sup 51/Cr and uptake of trypan blue dye were seen with 10/sup -5/M Hg/sup + +/ and Ag/sup +/. Inhibition of amino acid incorporation into protein-like material was seen with eluates of amalgam and with ionic solutions of most metals comprising dental amalgam. Stannous ion showed little if any cytotoxic potential. These results suggest that corrosion products of amalgam are capable of causing cellular injury or destruction.
Authors:
Goldschmidt, P R; Cogen, R B; Taubman, S B [1] 
  1. Departments of Periodontics and Pathology, University of Connecticut Health Center, Farmington, Connecticut, U.S.A.
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-299029; EDB-77-063971
Resource Relation:
Journal Name: J. Periodontal Res.; (Denmark); Journal Volume: 11
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CORROSION PRODUCTS; BIOLOGICAL EFFECTS; MERCURY ALLOYS; TIN IONS; AMINO ACIDS; CELL CULTURES; CHROMIUM 51; DENTISTRY; FIBROBLASTS; ALLOYS; ANIMAL CELLS; ATOMIC IONS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHARGED PARTICLES; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; IONS; ISOTOPES; MEDICINE; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; SOMATIC CELLS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
7122394
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JPDRA
Submitting Site:
INIS
Size:
Pages: 108-115
Announcement Date:
Apr 01, 1977

Citation Formats

Goldschmidt, P R, Cogen, R B, and Taubman, S B. Effects of amalgam corrosion products on human cells. Denmark: N. p., 1976. Web. doi:10.1111/j.1600-0765.1976.tb00058.x.
Goldschmidt, P R, Cogen, R B, & Taubman, S B. Effects of amalgam corrosion products on human cells. Denmark. doi:10.1111/j.1600-0765.1976.tb00058.x.
Goldschmidt, P R, Cogen, R B, and Taubman, S B. 1976. "Effects of amalgam corrosion products on human cells." Denmark. doi:10.1111/j.1600-0765.1976.tb00058.x. https://www.osti.gov/servlets/purl/10.1111/j.1600-0765.1976.tb00058.x.
@misc{etde_7122394,
title = {Effects of amalgam corrosion products on human cells}
author = {Goldschmidt, P R, Cogen, R B, and Taubman, S B}
abstractNote = {Using three independent criteria, we have found that 10/sup -4/,10/sup -6/M concentrations of ions presumably liberated from the corrosion of dental amalgam produce injurious effects on either human gingival fibroblasts or HeLa cells when the cells are grown in culture. Release of /sup 51/Cr and uptake of trypan blue dye were seen with 10/sup -5/M Hg/sup + +/ and Ag/sup +/. Inhibition of amino acid incorporation into protein-like material was seen with eluates of amalgam and with ionic solutions of most metals comprising dental amalgam. Stannous ion showed little if any cytotoxic potential. These results suggest that corrosion products of amalgam are capable of causing cellular injury or destruction.}
doi = {10.1111/j.1600-0765.1976.tb00058.x}
journal = {J. Periodontal Res.; (Denmark)}
volume = {11}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}