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Effects of radiation on the skin blood volume pulse in humans

Journal Article:

Abstract

Measurements have been made of the changes in skin blood volume pulse (BVP) in the irradiated skin of three patients (two female, one male) during and up to 250 days after radiotherapy for malignant disease. The instrumentation comprised a modified commercial finger photo-plethysmograph probe with associated electronics, and a survey of the literature revealed that the consensus of opinion seems to be that the recorded pulsations arise from small 'muscular' arteries and arterioles in the 40 to 300 ..mu..m size range. The results show that, as expected, normal, untreated skin shows sizeable variations in BVP. The BVP of irradiated skin became significantly greater than that of normal skin when a dose of 1000 to 1500 rad has been accumulated. The maximum amplitude of the BVP of the irradiated skin seemed to correlate well with the overall severity of the erythema, but increases in BVP preceded erythema flare-ups. In two patients, elevated BVP were recorded for irradiated areas even when most visual signs of erythema had disappeared. Mild cooling of irradiated and non-irradiated skin had differing effects in the BVP. The measurement of the BVP of irradiated skin is a simple, reliable and completely atraumatic method for investigating vascular damage to  More>>
Authors:
Zanelli, G D [1] 
  1. Mount Vernon Hospital, Northwood (UK)
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-298936; EDB-77-064352
Resource Relation:
Journal Name: Br. J. Radiol.; (United Kingdom); Journal Volume: 50:589
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD VESSELS; BIOLOGICAL RADIATION EFFECTS; BLOOD FLOW; BLOOD PRESSURE; COMPARATIVE EVALUATIONS; DIAGNOSTIC TECHNIQUES; DOSE-RESPONSE RELATIONSHIPS; ERYTHEMA; MAN; MEASURING METHODS; PATIENTS; RADIATION INJURIES; SKIN; TIME DEPENDENCE; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARDIOVASCULAR SYSTEM; INJURIES; MAMMALS; ORGANS; PRIMATES; RADIATION EFFECTS; SYMPTOMS; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7122278
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJRAA
Submitting Site:
INIS
Size:
Pages: 68-70
Announcement Date:

Journal Article:

Citation Formats

Zanelli, G D. Effects of radiation on the skin blood volume pulse in humans. United Kingdom: N. p., 1977. Web.
Zanelli, G D. Effects of radiation on the skin blood volume pulse in humans. United Kingdom.
Zanelli, G D. 1977. "Effects of radiation on the skin blood volume pulse in humans." United Kingdom.
@misc{etde_7122278,
title = {Effects of radiation on the skin blood volume pulse in humans}
author = {Zanelli, G D}
abstractNote = {Measurements have been made of the changes in skin blood volume pulse (BVP) in the irradiated skin of three patients (two female, one male) during and up to 250 days after radiotherapy for malignant disease. The instrumentation comprised a modified commercial finger photo-plethysmograph probe with associated electronics, and a survey of the literature revealed that the consensus of opinion seems to be that the recorded pulsations arise from small 'muscular' arteries and arterioles in the 40 to 300 ..mu..m size range. The results show that, as expected, normal, untreated skin shows sizeable variations in BVP. The BVP of irradiated skin became significantly greater than that of normal skin when a dose of 1000 to 1500 rad has been accumulated. The maximum amplitude of the BVP of the irradiated skin seemed to correlate well with the overall severity of the erythema, but increases in BVP preceded erythema flare-ups. In two patients, elevated BVP were recorded for irradiated areas even when most visual signs of erythema had disappeared. Mild cooling of irradiated and non-irradiated skin had differing effects in the BVP. The measurement of the BVP of irradiated skin is a simple, reliable and completely atraumatic method for investigating vascular damage to superficial tissues in humans.}
journal = {Br. J. Radiol.; (United Kingdom)}
volume = {50:589}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Jan}
}