You need JavaScript to view this

Skin response to X-irradiation in the guinea-pig

Journal Article:

Abstract

Skin reaction to X-irradiation has been studied in the albino quinea-pig; early response in limited-field irradiations of the flank was comparable to that commonly seen in rodents, swine and man, and was dose-dependent with a dynamic range from mild erythema to moist desquamation. The peak early skin reaction was seen between 14 and 21 days after irradiation, and declined before 30 days except at the highest doses used. Fractionation of the X-ray dose at 24 hours resulted in a 'sparing' of about 340 rad. Permanent partial epilation was detectable at doses in excess of 1400 rad, and complete epilation at 1 year occurred in 50 per cent of irradiated fields at 1740 rad. Twenty-four hour two-dose fractionation resulted in a 'sparing' of about 500 rad for epilation. Palpable dermal 'fibrosis' was detectable at 3 months after irradiation in fields given more than 2070 rad, and at 1 year after irradiation in fields given more than 1800 rad; 50 per cent of fields showed palpable 'fibrosis' at 1 year at 1930 rad. Unlike domestic swine and man, skin fields in the quinea-pig showed no dimensional contraction after X-ray doses which produced gross early skin damage.
Authors:
Berry, R J; Mole, R H; Barnes, D W.H. [1] 
  1. Medical Research Council, Harwell (UK). Radiobiological Research Unit
Publication Date:
Dec 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-298889; EDB-77-070567
Resource Relation:
Journal Name: Int. J. Radiat. Biol.; (United Kingdom); Journal Volume: 30:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SKIN; DELAYED RADIATION EFFECTS; EARLY RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; EPILATION; ERYTHEMA; FIBROSIS; FRACTIONATED IRRADIATION; GUINEA PIGS; RADIATION INJURIES; RADIOSENSITIVITY; SKIN DISEASES; TIME DEPENDENCE; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RODENTS; SYMPTOMS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7120467
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJRBA
Submitting Site:
INIS
Size:
Pages: 535-541
Announcement Date:
Apr 01, 1977

Journal Article:

Citation Formats

Berry, R J, Mole, R H, and Barnes, D W.H. Skin response to X-irradiation in the guinea-pig. United Kingdom: N. p., 1976. Web.
Berry, R J, Mole, R H, & Barnes, D W.H. Skin response to X-irradiation in the guinea-pig. United Kingdom.
Berry, R J, Mole, R H, and Barnes, D W.H. 1976. "Skin response to X-irradiation in the guinea-pig." United Kingdom.
@misc{etde_7120467,
title = {Skin response to X-irradiation in the guinea-pig}
author = {Berry, R J, Mole, R H, and Barnes, D W.H.}
abstractNote = {Skin reaction to X-irradiation has been studied in the albino quinea-pig; early response in limited-field irradiations of the flank was comparable to that commonly seen in rodents, swine and man, and was dose-dependent with a dynamic range from mild erythema to moist desquamation. The peak early skin reaction was seen between 14 and 21 days after irradiation, and declined before 30 days except at the highest doses used. Fractionation of the X-ray dose at 24 hours resulted in a 'sparing' of about 340 rad. Permanent partial epilation was detectable at doses in excess of 1400 rad, and complete epilation at 1 year occurred in 50 per cent of irradiated fields at 1740 rad. Twenty-four hour two-dose fractionation resulted in a 'sparing' of about 500 rad for epilation. Palpable dermal 'fibrosis' was detectable at 3 months after irradiation in fields given more than 2070 rad, and at 1 year after irradiation in fields given more than 1800 rad; 50 per cent of fields showed palpable 'fibrosis' at 1 year at 1930 rad. Unlike domestic swine and man, skin fields in the quinea-pig showed no dimensional contraction after X-ray doses which produced gross early skin damage.}
journal = {Int. J. Radiat. Biol.; (United Kingdom)}
volume = {30:6}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Dec}
}