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Bg1II polymorphism of the epidermal growth factor receptor (EGF-R) gene

Abstract

A 770 bp cDNA fragment was derived from the cytoplasmic portion of the EGF-R (ref. Libermann et al., 1985). Bg1II identifies 4 invariant bands of 7.0, 5.0, 3.5 and 1.2 kb and a two allele polymorphism with a band of either 10.6 kb (lane 1) or 9.4 kb (lane 3). An heterozygote individual is represented. The frequency was analyzed in 78 unrelated European Caucasians. Its chromosomal location was determined. Co-dominant segregation was demonstrated in three families of 12 individuals. A rare variant of 8.3 kb was seen in one chromosome out of the 144 examined. This allelic form has not yet been fully characterized.
Authors:
Biunno, I; Pozzi, M R; Radice, P; Mondini, P; Pierotti, M A; Porta, G D; [1]  Haley, J; Waterfield, M D [2] 
  1. Istituto Nazionale Tumori, Milan (Italy)
  2. Ludwig Institute for Cancer Research, London (England)
Publication Date:
Aug 11, 1988
Product Type:
Journal Article
Reference Number:
EDB-90-096470
Resource Relation:
Journal Name: Nucleic Acids Research; (UK); Journal Volume: 16:15
Subject:
59 BASIC BIOLOGICAL SCIENCES; RECOMBINANT DNA; AUTORADIOGRAPHY; RFLPS; GENETIC MAPPING; EPIDERMIS; GENES; GROWTH FACTORS; HUMAN POPULATIONS; HYBRIDIZATION; RECEPTORS; ANIMAL TISSUES; BODY; DNA; EPITHELIUM; MAPPING; MEMBRANE PROTEINS; MITOGENS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; POPULATIONS; PROTEINS; SKIN; TISSUES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
7118403
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0305-1048; CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 7753
Announcement Date:
Jul 01, 1990

Citation Formats

Biunno, I, Pozzi, M R, Radice, P, Mondini, P, Pierotti, M A, Porta, G D, Haley, J, and Waterfield, M D. Bg1II polymorphism of the epidermal growth factor receptor (EGF-R) gene. United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.15.7753.
Biunno, I, Pozzi, M R, Radice, P, Mondini, P, Pierotti, M A, Porta, G D, Haley, J, & Waterfield, M D. Bg1II polymorphism of the epidermal growth factor receptor (EGF-R) gene. United Kingdom. doi:10.1093/nar/16.15.7753.
Biunno, I, Pozzi, M R, Radice, P, Mondini, P, Pierotti, M A, Porta, G D, Haley, J, and Waterfield, M D. 1988. "Bg1II polymorphism of the epidermal growth factor receptor (EGF-R) gene." United Kingdom. doi:10.1093/nar/16.15.7753. https://www.osti.gov/servlets/purl/10.1093/nar/16.15.7753.
@misc{etde_7118403,
title = {Bg1II polymorphism of the epidermal growth factor receptor (EGF-R) gene}
author = {Biunno, I, Pozzi, M R, Radice, P, Mondini, P, Pierotti, M A, Porta, G D, Haley, J, and Waterfield, M D}
abstractNote = {A 770 bp cDNA fragment was derived from the cytoplasmic portion of the EGF-R (ref. Libermann et al., 1985). Bg1II identifies 4 invariant bands of 7.0, 5.0, 3.5 and 1.2 kb and a two allele polymorphism with a band of either 10.6 kb (lane 1) or 9.4 kb (lane 3). An heterozygote individual is represented. The frequency was analyzed in 78 unrelated European Caucasians. Its chromosomal location was determined. Co-dominant segregation was demonstrated in three families of 12 individuals. A rare variant of 8.3 kb was seen in one chromosome out of the 144 examined. This allelic form has not yet been fully characterized.}
doi = {10.1093/nar/16.15.7753}
journal = {Nucleic Acids Research; (UK)}
volume = {16:15}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Aug}
}