Abstract
This paper describes a non-invasive double nuclide technique for the simultaneous measurement of minimal cardiac transit times (MTT) and regional 'myocardial appearance times' (MAT) using gamma camera and computer. MAT is defined as the time lag between the appearance of an indicator with myocardial affinity in the aortic root and its extraction in the myocardial cells. The extraction can be identified as an increase of the ratio between the count rates of the two nuclides e.g. /sup 201/Tl-chloride and sup(113m)In DTPA. The clinical evaluation of this method allows the following conclusions: 1) MAT, determined over several circumscript myocardial regions permits the qualitative diagnosis of a coronary artery disease with high confidence. 2) Indices of nutritive myocardial blood flow (INF), derived by MAT using several representative areas of myocardium, show a definite correlation to the degree of coronary artery disease. In addition to the localization of infarction and the determination of infarct size, the technique described promises a quantitative evaluation of the regional myocardial perfusion. Simultaneously measured MTT help to assess segmental cardiac performance.
Knapp, W H;
Doll, J;
Georgi, P;
[1]
Tillmanns, H
[2]
- Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Nuklearmedizin
- Heidelberg Univ. (Germany, F.R.). Innere Medizin 3
Citation Formats
Knapp, W H, Doll, J, Georgi, P, and Tillmanns, H.
Quantitative evaluation of myocardial perfusion and heart function using a non-invasive double isotope technique.
Germany: N. p.,
1976.
Web.
Knapp, W H, Doll, J, Georgi, P, & Tillmanns, H.
Quantitative evaluation of myocardial perfusion and heart function using a non-invasive double isotope technique.
Germany.
Knapp, W H, Doll, J, Georgi, P, and Tillmanns, H.
1976.
"Quantitative evaluation of myocardial perfusion and heart function using a non-invasive double isotope technique."
Germany.
@misc{etde_7106962,
title = {Quantitative evaluation of myocardial perfusion and heart function using a non-invasive double isotope technique}
author = {Knapp, W H, Doll, J, Georgi, P, and Tillmanns, H}
abstractNote = {This paper describes a non-invasive double nuclide technique for the simultaneous measurement of minimal cardiac transit times (MTT) and regional 'myocardial appearance times' (MAT) using gamma camera and computer. MAT is defined as the time lag between the appearance of an indicator with myocardial affinity in the aortic root and its extraction in the myocardial cells. The extraction can be identified as an increase of the ratio between the count rates of the two nuclides e.g. /sup 201/Tl-chloride and sup(113m)In DTPA. The clinical evaluation of this method allows the following conclusions: 1) MAT, determined over several circumscript myocardial regions permits the qualitative diagnosis of a coronary artery disease with high confidence. 2) Indices of nutritive myocardial blood flow (INF), derived by MAT using several representative areas of myocardium, show a definite correlation to the degree of coronary artery disease. In addition to the localization of infarction and the determination of infarct size, the technique described promises a quantitative evaluation of the regional myocardial perfusion. Simultaneously measured MTT help to assess segmental cardiac performance.}
journal = []
volume = {7:5}
journal type = {AC}
place = {Germany}
year = {1976}
month = {Nov}
}
title = {Quantitative evaluation of myocardial perfusion and heart function using a non-invasive double isotope technique}
author = {Knapp, W H, Doll, J, Georgi, P, and Tillmanns, H}
abstractNote = {This paper describes a non-invasive double nuclide technique for the simultaneous measurement of minimal cardiac transit times (MTT) and regional 'myocardial appearance times' (MAT) using gamma camera and computer. MAT is defined as the time lag between the appearance of an indicator with myocardial affinity in the aortic root and its extraction in the myocardial cells. The extraction can be identified as an increase of the ratio between the count rates of the two nuclides e.g. /sup 201/Tl-chloride and sup(113m)In DTPA. The clinical evaluation of this method allows the following conclusions: 1) MAT, determined over several circumscript myocardial regions permits the qualitative diagnosis of a coronary artery disease with high confidence. 2) Indices of nutritive myocardial blood flow (INF), derived by MAT using several representative areas of myocardium, show a definite correlation to the degree of coronary artery disease. In addition to the localization of infarction and the determination of infarct size, the technique described promises a quantitative evaluation of the regional myocardial perfusion. Simultaneously measured MTT help to assess segmental cardiac performance.}
journal = []
volume = {7:5}
journal type = {AC}
place = {Germany}
year = {1976}
month = {Nov}
}