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Response of the adrenal medulla to exogenous insulin in head X-irradiated dogs

Journal Article:

Abstract

The observed results on the secretory response of the adrenal medulla to exogenous insulin in dogs whose heads had been irradiated with 200 rad X-irradiation at a rate of 60.6 rad/min are reported. Approximately 20 h after irradiation 2 i.u. insulin/kg body weight was administered to both irradiated and control (non-irradiated) dogs. The secretion of both adrenaline and noradrenaline in five control dogs which received insulin had increased markedly 30 min after the injection and it was sustained over the first 120 min. Five irradiated dogs also responded to the injection of insulin by secreting appreciable amounts of both adrenaline and noradrenaline, but the responsiveness was considerably lower; adrenaline and noradrenaline secretion 30 and 60 min after the injection was 59 and 33% less than that caused by insulin in control animals respectively, and these differences were significant (P < 0.01). Since insulin induces hypoglycaemia and thereby leads to an increase in the adrenal medullary secretion through the central mechanism, the present results observed 1 day after X-irradiation of the head indicate that the susceptibility of the adrenomedullary activating mechanism in the central nervous system may be diminished considerably after X-irradiation, even at doses as low as 200 rad.
Authors:
Yamashita, K; Mieno, M; Shimizu, T [1] 
  1. Nagasaki Univ. (Japan). School of Medicine
Publication Date:
Dec 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-306230; EDB-77-109029
Resource Relation:
Journal Name: J. Endocrinol.; (United Kingdom); Journal Volume: 71:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEAD; BIOLOGICAL RADIATION EFFECTS; ADRENAL GLANDS; ADRENALINE; DOGS; EXTERNAL IRRADIATION; INSULIN; LOW DOSE IRRADIATION; NORADRENALINE; SECRETION; TIME DEPENDENCE; X RADIATION; ADRENAL HORMONES; ANIMALS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DRUGS; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; HORMONES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANS; PEPTIDE HORMONES; RADIATION EFFECTS; RADIATIONS; STEROID HORMONES; SYMPATHOMIMETICS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7106820
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JOENA
Submitting Site:
INIS
Size:
Pages: 447-448
Announcement Date:

Journal Article:

Citation Formats

Yamashita, K, Mieno, M, and Shimizu, T. Response of the adrenal medulla to exogenous insulin in head X-irradiated dogs. United Kingdom: N. p., 1976. Web.
Yamashita, K, Mieno, M, & Shimizu, T. Response of the adrenal medulla to exogenous insulin in head X-irradiated dogs. United Kingdom.
Yamashita, K, Mieno, M, and Shimizu, T. 1976. "Response of the adrenal medulla to exogenous insulin in head X-irradiated dogs." United Kingdom.
@misc{etde_7106820,
title = {Response of the adrenal medulla to exogenous insulin in head X-irradiated dogs}
author = {Yamashita, K, Mieno, M, and Shimizu, T}
abstractNote = {The observed results on the secretory response of the adrenal medulla to exogenous insulin in dogs whose heads had been irradiated with 200 rad X-irradiation at a rate of 60.6 rad/min are reported. Approximately 20 h after irradiation 2 i.u. insulin/kg body weight was administered to both irradiated and control (non-irradiated) dogs. The secretion of both adrenaline and noradrenaline in five control dogs which received insulin had increased markedly 30 min after the injection and it was sustained over the first 120 min. Five irradiated dogs also responded to the injection of insulin by secreting appreciable amounts of both adrenaline and noradrenaline, but the responsiveness was considerably lower; adrenaline and noradrenaline secretion 30 and 60 min after the injection was 59 and 33% less than that caused by insulin in control animals respectively, and these differences were significant (P < 0.01). Since insulin induces hypoglycaemia and thereby leads to an increase in the adrenal medullary secretion through the central mechanism, the present results observed 1 day after X-irradiation of the head indicate that the susceptibility of the adrenomedullary activating mechanism in the central nervous system may be diminished considerably after X-irradiation, even at doses as low as 200 rad.}
journal = {J. Endocrinol.; (United Kingdom)}
volume = {71:3}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Dec}
}