Abstract
A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatinephosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterized by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.
Isaacs, H;
Badenhorst, M;
[1]
Heffron, J J.A.
[2]
- University of the Witwatersrand, Johannesburg (South Africa). Department of Physiology
- University of the Witwatersrand, Johannesburg (South Africa). Department of Physiological Chemistry
Citation Formats
Isaacs, H, Badenhorst, M, and Heffron, J J.A.
Picture frame fibres in a carrier of the trait for malignant hyperpyrexia.
South Africa: N. p.,
1975.
Web.
Isaacs, H, Badenhorst, M, & Heffron, J J.A.
Picture frame fibres in a carrier of the trait for malignant hyperpyrexia.
South Africa.
Isaacs, H, Badenhorst, M, and Heffron, J J.A.
1975.
"Picture frame fibres in a carrier of the trait for malignant hyperpyrexia."
South Africa.
@misc{etde_7103954,
title = {Picture frame fibres in a carrier of the trait for malignant hyperpyrexia}
author = {Isaacs, H, Badenhorst, M, and Heffron, J J.A.}
abstractNote = {A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatinephosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterized by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.}
journal = []
volume = {49}
journal type = {AC}
place = {South Africa}
year = {1975}
month = {Nov}
}
title = {Picture frame fibres in a carrier of the trait for malignant hyperpyrexia}
author = {Isaacs, H, Badenhorst, M, and Heffron, J J.A.}
abstractNote = {A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatinephosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterized by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.}
journal = []
volume = {49}
journal type = {AC}
place = {South Africa}
year = {1975}
month = {Nov}
}