The authors consider the development of mathematical methods of solving quantum field theory problems from attempts of simple perfection of usual methods of quantum mechanics by elaborating the methods of perturbation theory and S-matrix, by working out the perturbation theory for quantum electrodynamics, and by applying dispersion relations and S-matrix for strong interactions. The method of dispersion relations results in the majority of radically new ways of describing the scattering amplitude. The grave disadvantage of all the methods is that they little define the dynamics of processes. The dynamic theory in the Heisenberg representation may be constructed on the basis of the axiomatic theory of S-matrix with the casuality condition. Another axiomatic direction has been recently developed; that is the so-called algebraic axiomatics which makes use of methods of Csup(*)-algebras.