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Effects of insulin on the survival of irradiated chinese hamster lung cells

Journal Article:

Abstract

Insulin treatment (10/sup -7/-10/sup -9/ M) before ..gamma.. irradiation (50 to 500 rads) increases the long term survival of Chinese hamster lung cells (DON). Our data indicates that the radioprotective effect of insulin is not due to a modulation of cyclic-adenosine-3',5'-monophosphate levels within these cells. The results suggest that the radiosensitive plasma membrane component postulated to be involved in the interphase death of thymocytes and protected by insulin may have a counterpart in DON cells.
Authors:
Lin, P S; Kwock, L; Hefter, K; Wallach, D F.H.; Brotman, R [1] 
  1. Tufts-New England Medical Center, Boston, Mass. (USA)
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-324643; EDB-77-148020
Resource Relation:
Journal Name: J. Mol. Med.; (Ireland); Journal Volume: 2:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; RADIOSENSITIVITY; INSULIN; RADIOSENSITIVITY EFFECTS; AMP; GAMMA RADIATION; HAMSTERS; PLASMA CELLS; RADIATION EFFECTS; RADIOPROTECTIVE SUBSTANCES; THYMOCYTES; ANIMALS; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; HORMONES; IONIZING RADIATIONS; MAMMALS; NUCLEOTIDES; ORGANIC COMPOUNDS; PEPTIDE HORMONES; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7091096
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JMMED
Submitting Site:
INIS
Size:
Pages: 83-87
Announcement Date:

Journal Article:

Citation Formats

Lin, P S, Kwock, L, Hefter, K, Wallach, D F.H., and Brotman, R. Effects of insulin on the survival of irradiated chinese hamster lung cells. Ireland: N. p., 1977. Web.
Lin, P S, Kwock, L, Hefter, K, Wallach, D F.H., & Brotman, R. Effects of insulin on the survival of irradiated chinese hamster lung cells. Ireland.
Lin, P S, Kwock, L, Hefter, K, Wallach, D F.H., and Brotman, R. 1977. "Effects of insulin on the survival of irradiated chinese hamster lung cells." Ireland.
@misc{etde_7091096,
title = {Effects of insulin on the survival of irradiated chinese hamster lung cells}
author = {Lin, P S, Kwock, L, Hefter, K, Wallach, D F.H., and Brotman, R}
abstractNote = {Insulin treatment (10/sup -7/-10/sup -9/ M) before ..gamma.. irradiation (50 to 500 rads) increases the long term survival of Chinese hamster lung cells (DON). Our data indicates that the radioprotective effect of insulin is not due to a modulation of cyclic-adenosine-3',5'-monophosphate levels within these cells. The results suggest that the radiosensitive plasma membrane component postulated to be involved in the interphase death of thymocytes and protected by insulin may have a counterpart in DON cells.}
journal = {J. Mol. Med.; (Ireland)}
volume = {2:1}
journal type = {AC}
place = {Ireland}
year = {1977}
month = {Jan}
}