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Metabolism and toxicity of therapeutic chelating agents Pt. 15. Effect of Ca-DTPA and Zn-DTPA on blood coagulation

Journal Article:

Abstract

Single subcutaneous injection of Ca-DTPA by a toxic dosage results in rats in a short-term moderate reduction of the plasma concentration of factors belonging to the endogenous coagulation system and of the prothrombin complex. Neither the temporary fibrinolysis nor the thrombocytopenia occurring later deeply affect coagulation as a whole. By fractionation of the daily dose or by continuous infusion of Ca-DTPA-damage to the plasmatic coagulation system is not further increased, although the intensity of thrombocytopenia is enhanced which is minimum after a single administration of the chelate. The platelet functions, on the other hand, are not influenced by Ca-DTPA. The much better compatibility of Zn-DTPA as compared to Ca-DTPA was fully confirmed also with respect to the hematological and coagulation parameters.
Authors:
Lohbreier, J [1] 
  1. Kernforschungszentrum Karlsruhe (Germany, F.R.). Inst. fuer Genetik und fuer Toxikologie von Spaltstoffen
Publication Date:
Oct 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-365476; EDB-78-091906
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 153:10
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD COAGULATION; PATHOLOGICAL CHANGES; CALCIUM COMPLEXES; TOXICITY; DTPA; ZINC COMPLEXES; BIOLOGICAL EFFECTS; BLOOD COAGULATION FACTORS; COMPARATIVE EVALUATIONS; DECONTAMINATION; FIBRINOLYSIS; HEALTH HAZARDS; HEMATOLOGY; INFUSION; INJECTION; RATS; ALKALINE EARTH METAL COMPLEXES; AMINO ACIDS; ANIMALS; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMICAL REACTIONS; CLEANING; COMPLEXES; DECOMPOSITION; DISEASES; DRUGS; HAZARDS; INTAKE; MAMMALS; MEDICINE; ORGANIC ACIDS; ORGANIC COMPOUNDS; PROTEOLYSIS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES; 550900* - Pathology; 550600 - Medicine; 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
7090896
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 704-710
Announcement Date:

Journal Article:

Citation Formats

Lohbreier, J. Metabolism and toxicity of therapeutic chelating agents Pt. 15. Effect of Ca-DTPA and Zn-DTPA on blood coagulation. Germany: N. p., 1977. Web.
Lohbreier, J. Metabolism and toxicity of therapeutic chelating agents Pt. 15. Effect of Ca-DTPA and Zn-DTPA on blood coagulation. Germany.
Lohbreier, J. 1977. "Metabolism and toxicity of therapeutic chelating agents Pt. 15. Effect of Ca-DTPA and Zn-DTPA on blood coagulation." Germany.
@misc{etde_7090896,
title = {Metabolism and toxicity of therapeutic chelating agents Pt. 15. Effect of Ca-DTPA and Zn-DTPA on blood coagulation}
author = {Lohbreier, J}
abstractNote = {Single subcutaneous injection of Ca-DTPA by a toxic dosage results in rats in a short-term moderate reduction of the plasma concentration of factors belonging to the endogenous coagulation system and of the prothrombin complex. Neither the temporary fibrinolysis nor the thrombocytopenia occurring later deeply affect coagulation as a whole. By fractionation of the daily dose or by continuous infusion of Ca-DTPA-damage to the plasmatic coagulation system is not further increased, although the intensity of thrombocytopenia is enhanced which is minimum after a single administration of the chelate. The platelet functions, on the other hand, are not influenced by Ca-DTPA. The much better compatibility of Zn-DTPA as compared to Ca-DTPA was fully confirmed also with respect to the hematological and coagulation parameters.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {153:10}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Oct}
}