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Exchangeable splenic platelet pool in response to intravenous infusion of isoprenaline

Journal Article:

Abstract

8 healthy volunteers and 4 asplenic subjects, in whom autologous platelets had been labelled with radioactive sodium chromate, received intravenous infusions of isoprenaline in a dose of 0.03 ..mu..g x kg/sup -1/ x min/sup -1/ over a period of 6 min. In the former group these infusions caused a significant decrease in the concentration of labelled as well as unlabelled platelets in the peripheral blood. Body surface countings showed that a significant increase in the count rate over the spleen occurred concomitantly with the decrease in the circulating platelet-bound radioactivity (PBR). In the group of asplenic subjects no change in PBR occurred. It is concluded that adrenergic beta-receptor stimulation causes a transitory trapping of platelets in the exchangeable splenic platelet pool.
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-395122; EDB-78-110676
Resource Relation:
Journal Name: Scand. J. Haematol.; (Denmark); Journal Volume: 20
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD PLATELETS; METABOLISM; CHROMIUM 51; LABELLED POOL TECHNIQUES; BODY AREAS; CHROMATES; DRUGS; INTRAVENOUS INJECTION; MAN; SPLEEN; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CHROMIUM COMPOUNDS; CHROMIUM ISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANS; OXYGEN COMPOUNDS; PRIMATES; RADIOISOTOPES; TRACER TECHNIQUES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7088415
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SJHAA
Submitting Site:
INIS
Size:
Pages: 335-340
Announcement Date:
Sep 01, 1978

Journal Article:

Citation Formats

Freden, K, Olsson, L B, Suurkula, M, and Kutti, J. Exchangeable splenic platelet pool in response to intravenous infusion of isoprenaline. Denmark: N. p., 1978. Web.
Freden, K, Olsson, L B, Suurkula, M, & Kutti, J. Exchangeable splenic platelet pool in response to intravenous infusion of isoprenaline. Denmark.
Freden, K, Olsson, L B, Suurkula, M, and Kutti, J. 1978. "Exchangeable splenic platelet pool in response to intravenous infusion of isoprenaline." Denmark.
@misc{etde_7088415,
title = {Exchangeable splenic platelet pool in response to intravenous infusion of isoprenaline}
author = {Freden, K, Olsson, L B, Suurkula, M, and Kutti, J}
abstractNote = {8 healthy volunteers and 4 asplenic subjects, in whom autologous platelets had been labelled with radioactive sodium chromate, received intravenous infusions of isoprenaline in a dose of 0.03 ..mu..g x kg/sup -1/ x min/sup -1/ over a period of 6 min. In the former group these infusions caused a significant decrease in the concentration of labelled as well as unlabelled platelets in the peripheral blood. Body surface countings showed that a significant increase in the count rate over the spleen occurred concomitantly with the decrease in the circulating platelet-bound radioactivity (PBR). In the group of asplenic subjects no change in PBR occurred. It is concluded that adrenergic beta-receptor stimulation causes a transitory trapping of platelets in the exchangeable splenic platelet pool.}
journal = {Scand. J. Haematol.; (Denmark)}
volume = {20}
journal type = {AC}
place = {Denmark}
year = {1978}
month = {Jan}
}