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Ultrastructural alterations in ciliary cells exposed to ionizing radiation. A scanning and transmission electron microscopic study

Journal Article:

Abstract

Early effects of ionizing radiation were investigated in an experimental in vitro system using the ciliary cells of the tracheal mucous membrane of the rabbit, irradiated at 30/sup 0/C and at more than 90% humidity. The changes in physiological activities of the ciliary cells caused by irradation were continously registered during the irradation. The specimens were examined immediately after irradiation electron microscopically. The morphological changes in irradiated material after 10-70 Gy are compared with normal material. After 40-70 Gy, scanning electron microscopy revealed the formation of vesicles on cilia, and club-like protrusions and adhesion of their tips. After 30-70 Gy, a swelling of mitochondrial membranes and cristae was apparent transmission electron microscopically. The membrane alterations caused by irradiation are assumed to disturb the permeability and flow of ATP from the mitochondria, which in turn leads to the recorded changes in the activity of the ciliated cells.
Authors:
Baldetorp, L; Mecklenburg, C v; Haakansson, C H; [1]  Lund Univ. (Sweden). Dept. of Zoology)
  1. Lund Univ. (Sweden). Hospital
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-395017; EDB-78-110850
Resource Relation:
Journal Name: Cell Tissue Res.; (Germany, Federal Republic of); Journal Volume: 180:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; MITOCHONDRIA; MORPHOLOGICAL CHANGES; MUCOUS MEMBRANES; ATP; EARLY RADIATION EFFECTS; ELECTRON MICROSCOPY; HUMIDITY; IN VITRO; IONIZING RADIATIONS; PERMEABILITY; PHYSIOLOGY; RABBITS; SCINTISCANNING; TEMPERATURE DEPENDENCE; TRACHEA; ANIMALS; BIOLOGICAL EFFECTS; CELL CONSTITUENTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; MAMMALS; MICROSCOPY; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPE SCANNING; RESPIRATORY SYSTEM; VERTEBRATES; 560114* - Radiation Effects on Biochemicals- In Animals- (-1987); 560121 - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7087097
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTSRC
Submitting Site:
INIS
Size:
Pages: 421-431
Announcement Date:

Journal Article:

Citation Formats

Baldetorp, L, Mecklenburg, C v, Haakansson, C H, and Lund Univ. (Sweden). Dept. of Zoology). Ultrastructural alterations in ciliary cells exposed to ionizing radiation. A scanning and transmission electron microscopic study. Germany: N. p., 1977. Web.
Baldetorp, L, Mecklenburg, C v, Haakansson, C H, & Lund Univ. (Sweden). Dept. of Zoology). Ultrastructural alterations in ciliary cells exposed to ionizing radiation. A scanning and transmission electron microscopic study. Germany.
Baldetorp, L, Mecklenburg, C v, Haakansson, C H, and Lund Univ. (Sweden). Dept. of Zoology). 1977. "Ultrastructural alterations in ciliary cells exposed to ionizing radiation. A scanning and transmission electron microscopic study." Germany.
@misc{etde_7087097,
title = {Ultrastructural alterations in ciliary cells exposed to ionizing radiation. A scanning and transmission electron microscopic study}
author = {Baldetorp, L, Mecklenburg, C v, Haakansson, C H, and Lund Univ. (Sweden). Dept. of Zoology)}
abstractNote = {Early effects of ionizing radiation were investigated in an experimental in vitro system using the ciliary cells of the tracheal mucous membrane of the rabbit, irradiated at 30/sup 0/C and at more than 90% humidity. The changes in physiological activities of the ciliary cells caused by irradation were continously registered during the irradation. The specimens were examined immediately after irradiation electron microscopically. The morphological changes in irradiated material after 10-70 Gy are compared with normal material. After 40-70 Gy, scanning electron microscopy revealed the formation of vesicles on cilia, and club-like protrusions and adhesion of their tips. After 30-70 Gy, a swelling of mitochondrial membranes and cristae was apparent transmission electron microscopically. The membrane alterations caused by irradiation are assumed to disturb the permeability and flow of ATP from the mitochondria, which in turn leads to the recorded changes in the activity of the ciliated cells.}
journal = {Cell Tissue Res.; (Germany, Federal Republic of)}
volume = {180:4}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jan}
}