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Bone marrow transplantation for an infant with neutrophil dysfunction

Journal Article:

Abstract

A child with severe neutrophil dysfunction and intractable infections received bone marrow transplants from histocompatible siblings. After a first transplant preceded by cyclophosphamide (CY), antithymocyte serum (ATS) and procarbazine (PCB) preconditioning, there was no evidence for engraftment and autologous marrow function rapidly returned. Cell mediated lysis showed no evidence of patient sensitization against the marrow donor suggesting that graft rejection did not cause the transplant failure. A second transplant was performed utilizing another matched sibling donor. Total body irradiation was added to CY, ATS, and PCB for preconditioning after in vitro studies of the colony forming capacity (CFUsub(c)) of the patient's marrow cells showed normal sensitivity to radiation. Full engraftment ensued with correction of granulocyte function abnormalities. The patient eventually died of intractable pulmonary disease. Experience with this child suggests that cyclophosphamide alone may be insufficient preparation for marrow transplantation in some patients with non-neoplastic hematologic disorders. Experimental and clinical data supporting this contention are reviewed.
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-332438; EDB-78-011206
Resource Relation:
Journal Name: Exp. Hematol.; (Denmark); Journal Volume: 5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; IMMUNE REACTIONS; BIOLOGICAL RADIATION EFFECTS; IMMUNOSUPPRESSION; RADIOINDUCTION; CHILDREN; ENDOXAN; HEMIC DISEASES; NEUTROPHILS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMALS; ANTIMITOTIC DRUGS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; IRRADIATION; LEUKOCYTES; MAMMALS; MAN; ORGANS; PRIMATES; RADIATION EFFECTS; TISSUES; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7083143
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXHEB
Submitting Site:
INIS
Size:
Pages: 109-116
Announcement Date:

Journal Article:

Citation Formats

Camitta, B M, Quesenberry, P J, Parkman, R, Boxer, L A, Stossel, T P, Cassady, J R, Rappeport, J M, Nathan, D G, and Tufts Univ., Boston, Mass. (USA). School of Medicine). Bone marrow transplantation for an infant with neutrophil dysfunction. Denmark: N. p., 1977. Web.
Camitta, B M, Quesenberry, P J, Parkman, R, Boxer, L A, Stossel, T P, Cassady, J R, Rappeport, J M, Nathan, D G, & Tufts Univ., Boston, Mass. (USA). School of Medicine). Bone marrow transplantation for an infant with neutrophil dysfunction. Denmark.
Camitta, B M, Quesenberry, P J, Parkman, R, Boxer, L A, Stossel, T P, Cassady, J R, Rappeport, J M, Nathan, D G, and Tufts Univ., Boston, Mass. (USA). School of Medicine). 1977. "Bone marrow transplantation for an infant with neutrophil dysfunction." Denmark.
@misc{etde_7083143,
title = {Bone marrow transplantation for an infant with neutrophil dysfunction}
author = {Camitta, B M, Quesenberry, P J, Parkman, R, Boxer, L A, Stossel, T P, Cassady, J R, Rappeport, J M, Nathan, D G, and Tufts Univ., Boston, Mass. (USA). School of Medicine)}
abstractNote = {A child with severe neutrophil dysfunction and intractable infections received bone marrow transplants from histocompatible siblings. After a first transplant preceded by cyclophosphamide (CY), antithymocyte serum (ATS) and procarbazine (PCB) preconditioning, there was no evidence for engraftment and autologous marrow function rapidly returned. Cell mediated lysis showed no evidence of patient sensitization against the marrow donor suggesting that graft rejection did not cause the transplant failure. A second transplant was performed utilizing another matched sibling donor. Total body irradiation was added to CY, ATS, and PCB for preconditioning after in vitro studies of the colony forming capacity (CFUsub(c)) of the patient's marrow cells showed normal sensitivity to radiation. Full engraftment ensued with correction of granulocyte function abnormalities. The patient eventually died of intractable pulmonary disease. Experience with this child suggests that cyclophosphamide alone may be insufficient preparation for marrow transplantation in some patients with non-neoplastic hematologic disorders. Experimental and clinical data supporting this contention are reviewed.}
journal = {Exp. Hematol.; (Denmark)}
volume = {5}
journal type = {AC}
place = {Denmark}
year = {1977}
month = {Jan}
}