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Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain

Journal Article:

Abstract

Suckling rats were exposed for 15 and 30 days to manganese through the milk of nursing dams receiving 15 mg MnCl/sub 2/.4H/sub 2/O/kg/day orally and after which the neurological manifestations of metal poisoning were studied. No significant differences in the growth rate, developmental landmarks and walking movements were observed between the control and manganese-exposed pups. The metal concentration was significantly increased in the brain of manganese-fed pups at 15 days and exhibited a further three-fold increase over the control, at 30 days. The accumulation of the metal in the brain of manganese-exposed nursing dams was comparatively much less. A significant decrease in succinic dehydrogenase, adenosine triphosphatase, adenosine deaminase, acetylcholine esterase and an increase in monoamine oxidase activity was observed in the brain of experimental pups and dams. The results suggest that the developing brain may also be susceptible to manganese.
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
ERA-03-009113; EDB-78-011405
Resource Relation:
Journal Name: Acta Pharmacol. Toxicol.; (Denmark); Journal Volume: 40:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MAGNESIUM; BIOLOGICAL ACCUMULATION; BIOLOGICAL EFFECTS; ACETYLCHOLINE; ADENOSINE; AMINES; ATP; BRAIN; CATALYSIS; DEAMINATION; DEHYDROGENASES; ENZYMES; FEEDING; GROWTH; MANGANESE CHLORIDES; METABOLISM; METALS; MILK; NEONATES; NEUROLOGY; OXIDASES; QUANTITY RATIO; RATS; TOXICITY; ALKALINE EARTH METALS; AMMONIUM COMPOUNDS; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; CHEMICAL REACTIONS; CHLORIDES; CHLORINE COMPOUNDS; DRUGS; ELEMENTS; ESTERS; FOOD; HALIDES; HALOGEN COMPOUNDS; MAMMALS; MANGANESE COMPOUNDS; MANGANESE HALIDES; MEDICINE; NERVOUS SYSTEM; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PARASYMPATHOMIMETICS; QUATERNARY COMPOUNDS; RIBOSIDES; RODENTS; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
7082952
Research Organizations:
Industrial Toxicology Research Centre, Lucknow, India
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: APTOA
Submitting Site:
TIC
Size:
Pages: 553-560
Announcement Date:

Journal Article:

Citation Formats

Seth, P K, Husain, R, Mushtaq, M, and Chandra, S V. Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain. Denmark: N. p., 1977. Web.
Seth, P K, Husain, R, Mushtaq, M, & Chandra, S V. Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain. Denmark.
Seth, P K, Husain, R, Mushtaq, M, and Chandra, S V. 1977. "Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain." Denmark.
@misc{etde_7082952,
title = {Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain}
author = {Seth, P K, Husain, R, Mushtaq, M, and Chandra, S V}
abstractNote = {Suckling rats were exposed for 15 and 30 days to manganese through the milk of nursing dams receiving 15 mg MnCl/sub 2/.4H/sub 2/O/kg/day orally and after which the neurological manifestations of metal poisoning were studied. No significant differences in the growth rate, developmental landmarks and walking movements were observed between the control and manganese-exposed pups. The metal concentration was significantly increased in the brain of manganese-fed pups at 15 days and exhibited a further three-fold increase over the control, at 30 days. The accumulation of the metal in the brain of manganese-exposed nursing dams was comparatively much less. A significant decrease in succinic dehydrogenase, adenosine triphosphatase, adenosine deaminase, acetylcholine esterase and an increase in monoamine oxidase activity was observed in the brain of experimental pups and dams. The results suggest that the developing brain may also be susceptible to manganese.}
journal = {Acta Pharmacol. Toxicol.; (Denmark)}
volume = {40:5}
journal type = {AC}
place = {Denmark}
year = {1977}
month = {Jan}
}