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Ultrastructural studies on the blood-brain barrier. Mainly as to changes in the permeability of cerebral capillary walls induced by experimental x-ray irradiation and the effect of glucocorticoid on such changes

Journal Article:

Abstract

In the present study, an ultrastructural examination was made of the role of capillary endothelial cells of the brain which is one of the constituent factors of the blood-brain barrier. In normal cerebral capillaries, both endothelial cells and the basement membrane were demonstrated to be not crossed by a tracer (horseradish peroxidase) even in 60 minutes after its intravenous administration, thus suggesting the blood-brain barrier effect. Author investigated changes in the permeability of cerebral capillary walls induced by experimental brain irradiation and the effect of glucocorticoid on such changes. On forty-eight hours following an appropriate irradiation a marked brain edema was developed; under such circumstances when the tracer was injected intravenously, on 60 minutes thereafter the tracer was demonstrated to be transferred into the neutral tissue, and this was interpreted as indicating that capillary hyperpermeability was induced. These findings were suggested that the mechanism of capillary hyperpermeability might not be based on the passage of a tight junction of the cells of capillary wall but rather on account of activated active transport via an increased number of pinocytotic vesicles. The mechanism of increase of pinocytotic vesicle appeared to be resulting from a breakdown of the controlling system of pinocytotic vesicle  More>>
Authors:
Ichitsubo, H [1] 
  1. Tokyo Medical Coll. (Japan)
Publication Date:
Mar 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-367498; EDB-78-081709
Resource Relation:
Journal Name: Tokyo Ika Daigaku Zasshi; (Japan); Journal Volume: 35:2; Other Information: Contains 106 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD-BRAIN BARRIER; BIOLOGICAL RADIATION EFFECTS; ULTRASTRUCTURAL CHANGES; CAPILLARIES; GLUCOCORTICOIDS; RADIOSENSITIVITY EFFECTS; BIBLIOGRAPHIES; BRAIN; ENDOTHELIUM; IRRADIATION; METABOLISM; MICE; PERMEABILITY; X RADIATION; ADRENAL HORMONES; ANIMALS; BIOLOGICAL EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CORTICOSTEROIDS; DOCUMENT TYPES; ELECTROMAGNETIC RADIATION; HORMONES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; KETONES; MAMMALS; MORPHOLOGICAL CHANGES; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; PREGNANES; RADIATION EFFECTS; RADIATIONS; RODENTS; STEROID HORMONES; STEROIDS; TISSUES; VERTEBRATES; 560150* - Radiation Effects on Animals
OSTI ID:
7075724
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: TIDZA
Submitting Site:
INIS
Size:
Pages: 183-201
Announcement Date:

Journal Article:

Citation Formats

Ichitsubo, H. Ultrastructural studies on the blood-brain barrier. Mainly as to changes in the permeability of cerebral capillary walls induced by experimental x-ray irradiation and the effect of glucocorticoid on such changes. Japan: N. p., 1977. Web.
Ichitsubo, H. Ultrastructural studies on the blood-brain barrier. Mainly as to changes in the permeability of cerebral capillary walls induced by experimental x-ray irradiation and the effect of glucocorticoid on such changes. Japan.
Ichitsubo, H. 1977. "Ultrastructural studies on the blood-brain barrier. Mainly as to changes in the permeability of cerebral capillary walls induced by experimental x-ray irradiation and the effect of glucocorticoid on such changes." Japan.
@misc{etde_7075724,
title = {Ultrastructural studies on the blood-brain barrier. Mainly as to changes in the permeability of cerebral capillary walls induced by experimental x-ray irradiation and the effect of glucocorticoid on such changes}
author = {Ichitsubo, H}
abstractNote = {In the present study, an ultrastructural examination was made of the role of capillary endothelial cells of the brain which is one of the constituent factors of the blood-brain barrier. In normal cerebral capillaries, both endothelial cells and the basement membrane were demonstrated to be not crossed by a tracer (horseradish peroxidase) even in 60 minutes after its intravenous administration, thus suggesting the blood-brain barrier effect. Author investigated changes in the permeability of cerebral capillary walls induced by experimental brain irradiation and the effect of glucocorticoid on such changes. On forty-eight hours following an appropriate irradiation a marked brain edema was developed; under such circumstances when the tracer was injected intravenously, on 60 minutes thereafter the tracer was demonstrated to be transferred into the neutral tissue, and this was interpreted as indicating that capillary hyperpermeability was induced. These findings were suggested that the mechanism of capillary hyperpermeability might not be based on the passage of a tight junction of the cells of capillary wall but rather on account of activated active transport via an increased number of pinocytotic vesicles. The mechanism of increase of pinocytotic vesicle appeared to be resulting from a breakdown of the controlling system of pinocytotic vesicle production. However, the existence of this controlling system is still speculative. Pre-and post-irradiation administration of glucocorticoid proved to be effective in the prevention of irradiation-induced hyperpermeability of cerebral capillaries, and to be indicating the possible usefulness of the drug for the maintenance or repair of the aforementioned system.}
journal = {Tokyo Ika Daigaku Zasshi; (Japan)}
volume = {35:2}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Mar}
}